The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5.
about
Quantitative description of ion transport via plasma membrane of yeast and small cellsSSD1 is integral to host defense peptide resistance in Candida albicans.Peptide-based Antifungal Therapies against Emerging Infections.Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans.Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides.Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.A structural model for facultative anion channels in an oligomeric membrane protein: the yeast TRK (K(+)) system.Synthetic histidine-rich peptides inhibit Candida species and other fungi in vitro: role of endocytosis and treatment implications.Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins.Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruptionDifferentially expressed proteins in derivatives of Candida albicans displaying a stable histatin 3-resistant phenotypePotassium Uptake Mediated by Trk1 Is Crucial for Candida glabrata Growth and Fitness.Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway.The P-113 fragment of histatin 5 requires a specific peptide sequence for intracellular translocation in Candida albicans, which is independent of cell wall binding.Candida albicans cell wall proteinsHuman lactoferrin induces apoptosis-like cell death in Candida albicans: critical role of K+-channel-mediated K+ effluxThe antifungal plant defensin AtPDF2.3 from Arabidopsis thaliana blocks potassium channels.Sensitivity of Candida albicans biofilm cells grown on denture acrylic to antifungal proteins and chlorhexidineHow does it kill?: understanding the candidacidal mechanism of salivary histatin 5.Endocytosis-mediated vacuolar accumulation of the human ApoE apolipoprotein-derived ApoEdpL-W antimicrobial peptide contributes to its antifungal activity in Candida albicans.Potassium and Sodium Transport in Yeast.Human Antimicrobial Peptides in Bodily Fluids: Current Knowledge and Therapeutic Perspectives in the Postantibiotic Era.The role of released ATP in killing Candida albicans and other extracellular microbial pathogens by cationic peptides.Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity.Pathogenic Candida species differ in the ability to grow at limiting potassium concentrations.Three Candida albicans potassium uptake systems differ in their ability to provide Saccharomyces cerevisiae trk1trk2 mutants with necessary potassium.
P2860
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P2860
The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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name
The TRK1 potassium transporter ...... cationic protein, Histatin 5.
@en
type
label
The TRK1 potassium transporter ...... cationic protein, Histatin 5.
@en
prefLabel
The TRK1 potassium transporter ...... cationic protein, Histatin 5.
@en
P2093
P2860
P356
P1476
The TRK1 potassium transporter ...... cationic protein, Histatin 5.
@en
P2093
Alberto Rivetta
Clifford L Slayman
Ge-Fei Zeng
Jianing N Sun
Mira Edgerton
Slavena Vylkova
P2860
P304
55060-55072
P356
10.1074/JBC.M411031200
P407
P577
2004-10-13T00:00:00Z