A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasis.
about
Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysisThe protease inhibitor bikunin, a novel anti-metastatic agentKunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cellsSuppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascadeInhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinaseCancer associated fibroblasts (CAFs) in tumor microenvironment.Interference with the urokinase plasminogen activator system: a promising therapy concept for solid tumours.Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis.Pathophysiology and diagnostic value of urinary trypsin inhibitors.Urokinase plasminogen activator system as a potential target for cancer therapy.Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells.uPA-silica-Particles (SP-uPA): a novel analytical system to investigate uPA-uPAR interaction and to test synthetic uPAR antagonists as potential cancer therapeutics.High level synthesis of recombinant soluble urokinase receptor (CD87) by ovarian cancer cells reduces intraperitoneal tumor growth and spread in nude mice.Characterization of binding properties of urinary trypsin inhibitor to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8.Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun-dependent signaling pathways.Serum levels of urokinase-type plasminogen activator in healthy dogs and oncologic canine patients.Challenges for drug discovery - a case study of urokinase receptor inhibitionHigh-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread.Characterization of the interaction between tumor necrosis factor-stimulated gene-6 and heparin: implications for the inhibition of plasmin in extracellular matrix microenvironments.
P2860
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P2860
A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasis.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
A bifunctional hybrid molecule ...... cell invasion and metastasis.
@en
type
label
A bifunctional hybrid molecule ...... cell invasion and metastasis.
@en
prefLabel
A bifunctional hybrid molecule ...... cell invasion and metastasis.
@en
P2093
P1433
P1476
A bifunctional hybrid molecule ...... cell invasion and metastasis.
@en
P2093
H Kobayashi
H Shinohara
Y Hirashima
P304
P356
10.1046/J.1432-1327.1998.2530817.X
P407
P577
1998-05-01T00:00:00Z