YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice. - Wikidata - wikimedia - TriplyDB

YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice.

YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice.

http://www.wikidata.org/entity/Q38335806

about

Future pharmacological treatments for substance use disorders Recent methods for measuring dopamine D3 receptor occupancy in vivo: importance for drug development Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2.Making Sense of: Sensitization in Schizophrenia Dopamine D3 receptor-preferring agonist enhances the subjective effects of cocaine in humans Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats Neuronal circuitry underlying the impact of D3 receptor ligands in drug addiction.Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development.Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone Implication of dopamine D3 receptor activation in the reversion of Parkinson's disease-related motivational deficits.Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration Increased vulnerability to cocaine in mice lacking dopamine D3 receptors Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists.Convergent functional genomics in addiction research - a translational approach to study candidate genes and gene networks Targeting the dopamine D3 receptor: an overview of drug design strategies.Nucleus accumbens dopamine/glutamate interaction switches modes to generate desire versus dread: D(1) alone for appetitive eating but D(1) and D(2) together for fear Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.Dopamine D3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs.The selective dopamine D3 receptor antagonist, SR 21502, reduces cue-induced reinstatement of heroin seeking and heroin conditioned place preference in rats.Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats The dopamine D3 receptor antagonist, SR 21502, facilitates extinction of cocaine conditioned place preference.Effects of chronic buspirone treatment on cocaine self-administration A selective D3 receptor antagonist YQA14 attenuates methamphetamine-induced behavioral sensitization and conditioned place preference in mice Y-QA31, a novel dopamine D3 receptor antagonist, exhibits antipsychotic-like properties in preclinical animal models of schizophrenia.Cocaine self-administration in dopamine D₃ receptor knockout mice.Dopamine D3 receptors regulate reconsolidation of cocaine memory.Dopamine D(3) receptor deletion or blockade attenuates cocaine-induced conditioned place preference in mice.Reduction of cocaine self-administration and D3 receptor-mediated behavior by two novel dopamine D3 receptor-selective partial agonists, OS-3-106 and WW-III-55 Medication discovery for addiction: translating the dopamine D3 receptor hypothesis.Blockade of D3 receptors by YQA14 inhibits cocaine's rewarding effects and relapse to drug-seeking behavior in rats.The effects of the preferential dopamine D(3) receptor antagonist S33138 on ethanol binge drinking in C57BL/6J mice.Rationale in support of the use of selective dopamine D₃ receptor antagonists for the pharmacotherapeutic management of substance use disorders.Dopamine D3 receptor antagonists: a patent review (2007 - 2012).Dopamine D3 receptors as a therapeutic target for methamphetamine dependence.Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition.Characterization of preclinical in vitro and in vivo ADME properties and prediction of human PK using a physiologically based pharmacokinetic model for YQA-14, a new dopamine D3 receptor antagonist candidate for treatment of drug addiction.Nucleus accumbens hyperpolarization-activated cyclic nucleotide-gated channels modulate methamphetamine self-administration in rats.

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YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice.

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J.1369-1600.2011.00317.X

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Addiction Biology

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YQA14: a novel dopamine D3 rec ...... in D3 receptor-knockout mice.

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Eliot L Gardner

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Jin Li

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József Gaál

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Ning Wu

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Ri-Fang Yang

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Rui Song

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Rui-Bin Su

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Xia Li

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Xiao-Qing Peng

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Zheng-Xiong Xi

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P2860

Dopamine receptors: from structure to function

Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A

Acute administration of the selective D3 receptor antagonist SB-277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats

Selective antagonism at dopamine D3 receptors prevents nicotine-triggered relapse to nicotine-seeking behavior

Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A

Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats

Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction

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