Model of glycoprotein hormone receptor ligand binding and signaling.
about
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptorThyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activationFunctional differences of invariant and highly conserved residues in the extracellular domain of the glycoprotein hormone receptorsThe antibodies against the computationally designed mimic of the glycoprotein hormone receptor transmembrane domain provide insights into receptor activation and suppress the constitutively activated receptor mutants.In silico study on binding specificity of gonadotropins and their receptors: design of a novel and selective peptidomimetic for human follicle stimulating hormone receptor.Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological functionDefining structural and functional dimensions of the extracellular thyrotropin receptor region.Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians.The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties.A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domainThe superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor.Only a portion of the small seatbelt loop in human choriogonadotropin appears capable of contacting the lutropin receptor.Use of protein knobs to characterize the position of conserved alpha-subunit regions in lutropin receptor complexes.Critical involvement of the hinge region of the follicle-stimulating hormone receptor in the activation of the receptor.Molecular characterization and quantification of the follicle-stimulating hormone receptor in turbot (Scophthalmus maximus).Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor.Structure and activation of the TSH receptor transmembrane domain.Molecular cloning, characterization, and expression analysis of luteinizing hormone receptor gene in turbot (Scophthalmus maximus).Follitropin receptors contain cryptic ligand binding sites.Cloning and expression analysis of follicle-stimulating hormone and luteinizing hormone receptor during the reproductive cycle in Korean rockfish (Sebastes schlegeli).
P2860
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P2860
Model of glycoprotein hormone receptor ligand binding and signaling.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
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name
Model of glycoprotein hormone receptor ligand binding and signaling.
@en
type
label
Model of glycoprotein hormone receptor ligand binding and signaling.
@en
prefLabel
Model of glycoprotein hormone receptor ligand binding and signaling.
@en
P2093
P2860
P356
P1476
Model of glycoprotein hormone receptor ligand binding and signaling.
@en
P2093
Donghui Cao
John E Kerrigan
Michael P Bernard
Rebecca V Myers
William R Moyle
Yongna Xing
P2860
P304
44442-44459
P356
10.1074/JBC.M406948200
P407
P577
2004-08-09T00:00:00Z