Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx.
about
SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infectionNew insights into an X-traordinary viral proteinSAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx ProteinIdentification and characterization of naturally occurring splice variants of SAMHD1HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasomeSAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by VpxSAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesSAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Interferon-alpha mediates restriction of human immunodeficiency virus type-1 replication in primary human macrophages at an early stage of replication.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory proteinCharacterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cells.HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells.The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradationDistinct characteristics of endometrial and decidual macrophages and regulation of their permissivity to HIV-1 infection by SAMHD1.Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells.HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expression.Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis.Phosphorylation of murine SAMHD1 regulates its antiretroviral activityEvidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells.CCR5 is a receptor for Staphylococcus aureus leukotoxin ED.Host restriction factors in retroviral infection: promises in virus-host interaction.Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supplyRestriction of diverse retroviruses by SAMHD1.HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradationInhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1.HIV accessory proteins versus host restriction factors.Primate and feline lentiviruses in current intrinsic immunity research: the cat is back.Cellular restriction factors of feline immunodeficiency virus.Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase.Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins.The Fourth Major Restriction Factor Against HIV/SIV.Restricting HIV the SAMHD1 way: through nucleotide starvation.
P2860
Q21089603-C286C512-C040-4C4C-9079-1F5F88B01CEDQ21131105-3009C483-CB08-422E-BB4B-563115AFD9F2Q21131138-18832362-CA48-4D31-B733-61FF5B7BFBFBQ21245040-0F748EF8-583C-4638-8A25-DA501F8957C7Q24338212-04207023-CDD9-4B7B-B92E-07598753C5C5Q24605940-43B884AA-FD2C-4D6A-8355-16437798B470Q24624362-0F64B258-5901-42E7-BAEA-637E56E3D7E0Q30421200-929C1243-0E45-4348-A452-84D90C54C1F5Q33728042-749EC41E-62C9-4F4B-8244-8DDD5EEBBBB3Q33891972-63148E13-F58F-4FF3-92A6-3C0091E57848Q33926275-C8E82519-94CB-439E-A462-E094A02FCC98Q34120302-8A748752-D11D-4CAB-9280-BA8CBB8B6499Q34256688-2ED2ABED-666F-4815-9F5B-C380266543DFQ34263217-99329607-64E4-4CAA-B581-1AE1B96AE4CFQ34299501-78D2E1A6-DEC8-4E2F-82FB-6ADD4956B2E6Q34547626-CD611A92-47C1-4920-9B21-0F17E932B18DQ34845553-0BC38A87-B0CA-40A3-931F-E8F67A750368Q34846363-F2AE8D73-EC05-4A8D-8D71-3C27F16C59E8Q34991106-643EEF8A-5D58-46BF-BDFE-C6EC1388B951Q35077587-E8396076-78A1-4089-81E3-B374880E42F0Q35225635-FFF3B996-5056-4113-8158-79D05C510881Q35851869-42DFBAFF-5E11-49CD-A42C-4098E81BA10AQ36370120-F7F4DA20-AB76-466D-91DB-5329A50CECEBQ36484010-AC2F997A-809C-47FF-9088-0E7757AF8F8EQ36508062-EF2C7112-E633-4247-AD87-48DA1AE861AAQ36548179-EA82DA29-4CC3-41E5-A626-963B1362593FQ36690563-494A57AB-D658-4D9E-A4DF-E95A595E9214Q36707281-715DFC0A-5974-4401-AB29-69266C9CF2D2Q36967370-E5F83398-8398-4197-8CC2-E2AFE2EF219BQ37252729-91806EC1-0EE9-4A38-A170-80CDAD04C815Q37252735-80470D71-B565-42BE-991C-8DE57C85DBF1Q37375080-F4E7964E-CBFB-4CB0-8697-01B51387675EQ37895745-55AB9ABE-9CBE-40A1-9851-0F3D613ACB74Q37954259-D4EA744B-43FB-4F19-B01A-146684C9875BQ38051813-CEEC4414-F83C-4049-A5D6-3BF5A76594A8Q40321547-924F7F90-6D66-4D7A-BF8F-060B66A94483Q41887927-384236A4-F8CF-415B-A8BE-BBD1DFFEDED1Q42755789-8E1BA23D-0D91-43A6-A83B-BD652D4F491AQ55056626-31352800-ED34-4F64-BCBE-A5B0DE89E17D
P2860
Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Evidence for an activation dom ...... an immunodeficiency virus Vpx.
@en
type
label
Evidence for an activation dom ...... an immunodeficiency virus Vpx.
@en
prefLabel
Evidence for an activation dom ...... an immunodeficiency virus Vpx.
@en
P2093
P2860
P356
P1433
P1476
Evidence for an activation dom ...... an immunodeficiency virus Vpx.
@en
P2093
Nathaniel R Landau
Nicole Sunseri
Thomas Gramberg
P2860
P304
P356
10.1128/JVI.01437-09
P407
P577
2009-11-18T00:00:00Z