Requirement of lysine residues outside of the proposed pentasaccharide binding region for high affinity heparin binding and activation of human antithrombin III.

Requirement of lysine residues outside of the proposed pentasaccharide binding region for high affinity heparin binding and activation of human antithrombin III.

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http://www.wikidata.org/entity/Q38353867
The anticoagulant activation of antithrombin by heparinProtease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IVA Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding ProteinsCloning of the full-length cDNA of porcine antithrombin III and comparison with its human homolog.Design of growth factor sequestering biomaterialsEstimating glycosaminoglycan-protein interaction affinity: water dominates the specific antithrombin-heparin interaction.Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding.Salmon antithrombin has only three carbohydrate side chains, and shows functional similarities to human beta-antithrombin.SERPIN regulation of factor XIa. The novel observation that protease nexin 1 in the presence of heparin is a more potent inhibitor of factor XIa than C1 inhibitor.Analysis of a structural determinant in thrombin-protease nexin 1 complexes that mediates clearance by the low density lipoprotein receptor-related protein.Antithrombin III phenylalanines 122 and 121 contribute to its high affinity for heparin and its conformational activation.Lysine residue 114 in human antithrombin III is required for heparin pentasaccharide-mediated activation.The efficient catabolism of thrombin-protease nexin 1 complexes is a synergistic mechanism that requires both the LDL receptor-related protein and cell surface heparins.A cell adhesive peptide from tropoelastin promotes sequential cell attachment and spreading via distinct receptors.Deconvolution of the fluorescence emission spectrum of human antithrombin and identification of the tryptophan residues that are responsive to heparin binding.Release rate controls biological activity of nerve growth factor released from fibrin matrices containing affinity-based delivery systems.
P2860

Requirement of lysine residues outside of the proposed pentasaccharide binding region for high affinity heparin binding and activation of human antithrombin III.

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http://www.wikidata.org/entity/Q38353867
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
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1996年學術文章
@zh-hant
name
Requirement of lysine residues ...... ion of human antithrombin III.
@en
type
label
Requirement of lysine residues ...... ion of human antithrombin III.
@en
prefLabel
Requirement of lysine residues ...... ion of human antithrombin III.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P356
P1433
P1476
Requirement of lysine residues ...... ion of human antithrombin III.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698