Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.
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The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosisThe Contribution of Peroxisome Proliferator-Activated Receptor Gamma to Cutaneous Wound HealingA synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responsesAnticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes.PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism.The aryl hydrocarbon receptor ligand ITE inhibits TGFβ1-induced human myofibroblast differentiationPeroxisome proliferator-activated receptor gamma ligands inhibit transforming growth factor-beta-induced, hyaluronan-dependent, T cell adhesion to orbital fibroblasts.Alteration in the Wnt microenvironment directly regulates molecular events leading to pulmonary senescenceElectrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism.Inhibitory effects of PPARγ ligands on TGF-β1-induced corneal myofibroblast transformation.Estrogenic modulation of inflammation-related genes in male rats following volume overloadInhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts.Fibrosis in systemic sclerosis: common and unique pathobiology.Thy-1 signals through PPARγ to promote lipofibroblast differentiation in the developing lung.Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases.Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animalsIonizing radiation induces myofibroblast differentiation via lactate dehydrogenaseSynthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-βPharmacologic inhibition of lactate production prevents myofibroblast differentiation.The pulmonary mesenchyme directs lung development.Asiatic acid isolated from Centella asiatica inhibits TGF-β1-induced collagen expression in human keloid fibroblasts via PPAR-γ activation.Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism.Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivoDeterminants of initiation and progression of idiopathic pulmonary fibrosis.Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy.Myofibroblast differentiation and survival in fibrotic disease.The Role of PPAR Gamma in Systemic Sclerosis.15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring.Expression of calponin in periglomerular myofibroblasts of rat kidney with experimental chronic injuriesThe Search for an Ideal Temporary Skin Substitute: AWBAT Plus, a Combination Product Wound Dressing Medical Device.Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-γ ligands in a cyclooxygenase-2-dependent manner.Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice.Activated human T lymphocytes inhibit TGFβ-induced fibroblast to myofibroblast differentiation via prostaglandins D2 and E2.Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise
P2860
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P2860
Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Electrophilic peroxisome proli ...... cts in human lung fibroblasts.
@en
type
label
Electrophilic peroxisome proli ...... cts in human lung fibroblasts.
@en
prefLabel
Electrophilic peroxisome proli ...... cts in human lung fibroblasts.
@en
P2093
P2860
P356
P1476
Electrophilic peroxisome proli ...... ects in human lung fibroblasts
@en
P2093
Ajit Kulkarni
Geniece M Lehmann
Heather E Ferguson
Krystel R Huxlin
Patricia J Sime
Richard P Phipps
P2860
P304
P356
10.1165/RCMB.2009-0006OC
P577
2009-03-13T00:00:00Z