Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion.
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Design of an engineered N-terminal HIV-1 gp41 trimer with enhanced stability and potencyStructural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41Membrane-anchored HIV-1 N-heptad repeat peptides are highly potent cell fusion inhibitors via an altered mode of actionAntibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.A novel fluorescence intensity screening assay identifies new low-molecular-weight inhibitors of the gp41 coiled-coil domain of human immunodeficiency virus type 1A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains.Sequestering of the prehairpin intermediate of gp41 by peptide N36Mut(e,g) potentiates the human immunodeficiency virus type 1 neutralizing activity of monoclonal antibodies directed against the N-terminal helical repeat of gp41Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutAffinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41Structure of a proteolytically resistant core from the severe acute respiratory syndrome coronavirus S2 fusion proteinVaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection.A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformationsNovel recombinant engineered gp41 N-terminal heptad repeat trimers and their potential as anti-HIV-1 therapeutics or microbicidesA human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitopeConformational changes in HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion and inactivation.Phages and HIV-1: from display to interplay.Virus-cell and cell-cell fusion mediated by the HIV-1 envelope glycoprotein is inhibited by short gp41 N-terminal membrane-anchored peptides lacking the critical pocket domain.Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.Single-chain protein mimetics of the N-terminal heptad-repeat region of gp41 with potential as anti-HIV-1 drugs.Synergistic inhibition of HIV-1 envelope-mediated membrane fusion by inhibitors targeting the N and C-terminal heptad repeats of gp41.Swapped-domain constructs of the glycoprotein-41 ectodomain are potent inhibitors of HIV infectionProgress in identifying peptides and small-molecule inhibitors targeted to gp41 of HIV-1.Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens.Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice.Characterization of the steric defense of the HIV-1 gp41 N-trimer region.Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coilNew carbohydrate specificity and HIV-1 fusion blocking activity of the cyanobacterial protein MVL: NMR, ITC and sedimentation equilibrium studies.Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency.Insight into the mechanisms of aminoglycoside derivatives interaction with HIV-1 entry steps and viral gene transcription.Escape from human immunodeficiency virus type 1 (HIV-1) entry inhibitors.Approaches for identification of HIV-1 entry inhibitors targeting gp41 pocketPeptide fusion inhibitors targeting the HIV-1 gp41: a patent review (2009 - 2014).Multimerized HIV-gp41-derived peptides as fusion inhibitors and vaccines.Characterization of the infectious salmon anemia virus fusion protein.A synthetic C34 trimer of HIV-1 gp41 shows significant increase in inhibition potency.The C34 Peptide Fusion Inhibitor Binds to the Six-Helix Bundle Core Domain of HIV-1 gp41 by Displacement of the C-Terminal Helical Repeat Region.
P2860
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P2860
Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Covalent trimers of the intern ...... envelope-mediated cell fusion.
@en
type
label
Covalent trimers of the intern ...... envelope-mediated cell fusion.
@en
prefLabel
Covalent trimers of the intern ...... envelope-mediated cell fusion.
@en
P2093
P2860
P356
P1476
Covalent trimers of the intern ...... envelope-mediated cell fusion
@en
P2093
Carole A Bewley
Issa Nesheiwat
John M Louis
LengChee Chang
P2860
P304
20278-20285
P356
10.1074/JBC.M301627200
P407
P577
2003-03-24T00:00:00Z