Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
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Interactomic and pharmacological insights on human sirt-1SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activatorRedox regulation of SIRT1 in inflammation and cellular senescenceStructures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanismSirtuin deacylases: a molecular link between metabolism and immunityDevelopment of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.Are sirtuins viable targets for improving healthspan and lifespan?Metabolic and neuropsychiatric effects of calorie restriction and sirtuinsPharmacological approaches to restore mitochondrial function.A patent review of sirtuin activators: an update.Sirtuin activators and inhibitors.Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review.Mitochondrial dysfunction in the pathophysiology of renal diseases.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products.Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes.Mass spectrometric studies on the in vitro generated metabolites of SIRT1 activating drugs for doping control purposes.Copper-catalyzed chalcogenation of imidazoheterocycles with sulfur/selenium powder and coumarinyl triflates.A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles.Theoretical approaches to identify the potent scaffold for human sirtuin1 activator: Bayesian modeling and density functional theory
P2860
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P2860
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
@en
type
label
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
@en
prefLabel
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
@en
P2093
P356
P1476
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
@en
P2093
Amy V Lynch
David J Gagne
David P Carney
Jean E Bemis
Jeremy S Disch
Jesse J Smith
Jill C Milne
Joseph J Nunes
Michael R Jirousek
P304
P356
10.1021/JM8012954
P407
P577
2009-03-01T00:00:00Z