An intronic splicing enhancer element in survival motor neuron (SMN) pre-mRNA.
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Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanismRole of RNA structure in regulating pre-mRNA splicingSpinal muscular atrophy: from gene discovery to clinical trialsSplicing therapy for neuromuscular diseaseA short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophyConserved secondary structures in Aspergillus.Intron 7 conserved sequence elements regulate the splicing of the SMN genes.Splicing of the Survival Motor Neuron genes and implications for treatment of SMATIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.Antisense oligonucleotides for the treatment of spinal muscular atrophy.A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2.Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron.In vivo selection reveals combinatorial controls that define a critical exon in the spinal muscular atrophy genes.Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.Spinal Muscular Atrophy Therapeutics: Where do we Stand?Targeting SR proteins improves SMN expression in spinal muscular atrophy cells.Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.An intronic element contributes to splicing repression in spinal muscular atrophy.Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer.The Silent Sway of Splicing by Synonymous SubstitutionsInfluence of RNA secondary structure on the pre-mRNA splicing process.PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion.Splicing regulation in spinal muscular atrophy by an RNA structure formed by long-distance interactions.Defective splicing, disease and therapy: searching for master checkpoints in exon definition.Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice.Molecular mechanisms of spinal muscular atrophy.Progress in therapeutic antisense applications for neuromuscular disorders.Dual masking of specific negative splicing regulatory elements resulted in maximal exon 7 inclusion of SMN2 gene.A study on genomic distribution and sequence features of human long inverted repeats reveals species-specific intronic inverted repeats.Pharmacology of Modulators of Alternative Splicing.Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy.Translational development of splice-modifying antisense oligomers.RNA structure is a key regulatory element in pathological ATM and CFTR pseudoexon inclusion events.Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes.Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse models.A structured RNA in hepatitis B virus post-transcriptional regulatory element represses alternative splicing in a sequence-independent and position-dependent manner.3' Splice site sequences of spinal muscular atrophy related SMN2 pre-mRNA include enhancers for nearby exons.Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes.
P2860
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P2860
An intronic splicing enhancer element in survival motor neuron (SMN) pre-mRNA.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年學術文章
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2003年學術文章
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name
An intronic splicing enhancer element in survival motor neuron (SMN) pre-mRNA.
@en
type
label
An intronic splicing enhancer element in survival motor neuron (SMN) pre-mRNA.
@en
prefLabel
An intronic splicing enhancer element in survival motor neuron (SMN) pre-mRNA.
@en
P2093
P2860
P356
P1476
An intronic splicing enhancer element in survival motor neuron (SMN) pre-mRNA.
@en
P2093
Hidenobu Miyaso
Hiroshi Miyajima
Kazunori Imaizumi
Masayo Okumura
Satoshi Higashide
Shinichi Kondo
P2860
P304
15825-15831
P356
10.1074/JBC.M209271200
P407
P577
2003-02-25T00:00:00Z