Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability
about
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelAPhospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targetingCrosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA bindingRegulation of mammalian transcription and splicing by Nuclear RNAiA Structural Basis for BRD2/4-Mediated Host Chromatin Interaction and Oligomer Assembly of Kaposi Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus LANA ProteinsBrd4 activates P-TEFb for RNA polymerase II CTD phosphorylationPhosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomesAbrogation of the Brd4-positive transcription elongation factor B complex by papillomavirus E2 protein contributes to viral oncogene repressionPapillomavirus interaction with cellular chromatin.Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosisNCoR1 mediates papillomavirus E8;E2C transcriptional repressionBrd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4.Peptoid ligands that bind selectively to phosphoproteins.An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.The cellular bromodomain protein Brd4 has multiple functions in E2-mediated papillomavirus transcription activationOncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domainsBET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA.Brd4 is displaced from HPV replication factories as they expand and amplify viral DNANRIP, a novel calmodulin binding protein, activates calcineurin to dephosphorylate human papillomavirus E2 protein.Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription.Identification and analysis of papillomavirus E2 protein binding sites in the human genome.Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movementCurrent understanding of the role of the Brd4 protein in the papillomavirus lifecycle.BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression.The papillomavirus E2 proteinsBrd4 regulation of papillomavirus protein E2 stability.Phospho-BRD4: transcription plasticity and drug targeting.Brd4-mediated nuclear retention of the papillomavirus E2 protein contributes to its stabilization in host cells.Involvement of Brd4 in different steps of the papillomavirus life cycle.The role of ubiquitin and ubiquitin-like modification systems in papillomavirus biology.Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression.Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication.Phosphorylation of the Bovine Papillomavirus E2 Protein on Tyrosine Regulates Its Transcription and Replication FunctionsAcetylation of conserved lysines in bovine papillomavirus E2 by p300.Expression of mitochondrial non-coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes.The human papillomavirus type 18 E2 protein is a cell cycle-dependent target of the SCFSkp2 ubiquitin ligase.The HPV E2-Host Protein-Protein Interactions: A Complex Hijacking of the Cellular Network.HPV Replication Regulation by Acetylation of a Conserved Lysine in the E2 Protein.
P2860
Q24293271-6636F7D3-E17B-49B1-8C1C-F9DA0945397EQ24308867-06BFA608-B743-4CBB-BDC8-111F02E62FA5Q24311663-72D57E16-D280-4EB2-A5D8-68A068ABA462Q26776412-FC06C446-FDE7-4C01-98B0-CC6A12FEDF83Q27680409-73FFE6FF-293D-4F47-B697-AA681B736620Q28240747-62C6D4F4-3FFE-452B-8047-8AB6E342C03CQ28544058-787BDB1D-F169-43FE-87CA-05F6DBBB94FBQ33558774-2F144E4C-6884-45A6-A379-A64B15D7B0AFQ33729502-5682A0B5-B706-4DA7-8973-5391A39DD737Q33792527-1C347D5B-A5A7-40F4-8DBC-D3AA1ECAEAFAQ33826645-C24927B0-2A03-45DC-AD78-162047FAD2FDQ33865654-C7A16D79-33DC-4E6A-8FC6-6AE9B8D554A0Q33956489-A74B0ED6-C2CB-4611-A606-8435FC9D5CFDQ34037337-8ACBADDF-3D61-4F13-ABF1-36AEA59FF4E4Q34102298-350A8997-3F1A-4EB6-91CF-9D0AF7182EF5Q34148509-CAFC0193-E714-4565-A341-8571B8418E1AQ34358853-9E1B0A59-BF6C-46E2-AD62-68B1F284EAC2Q34568110-B6914D9B-6511-469A-ABFC-CD7215DF0B88Q35053049-85ECC3D0-AC11-4CE1-AEAA-08E9F65EED49Q35077476-F77CD517-C7E0-46C1-922B-10E11148FC1FQ35562500-A31E9D18-05E9-4C12-8B9E-3149CA90B41FQ35666079-0226079D-5883-4638-9437-2600FD63793EQ35884158-D622E7BD-2DFE-478D-8F40-5B09828A9F2EQ36943823-6665AF69-018C-4CC6-83C8-195A4046E4C7Q37030691-4072DD7C-C439-45AE-8009-56CFA716B213Q37168360-CCBBA2FC-7B00-48F6-A0E4-7103880C023FQ37198619-6BFC401A-C6F9-4734-9160-232A6CC3CC37Q37333751-A86371FB-3A44-4F35-AB98-6736EF09A91EQ37424187-F9B3E3D3-4BC8-4687-A137-65292378186CQ37566747-7C695048-5C16-46C2-85B6-C43891CF9EB3Q37666241-6A7BDAD2-D053-4239-9F75-D2016147059EQ38254163-1FA1AE7A-EE98-4E06-AE14-BB92AF63653EQ38561398-F0CFD4AB-4F17-4422-A815-51CC149B1D9DQ39037424-A2AA25A6-BF80-49CD-9AC7-37058FF094C5Q39222547-46F5F75C-F3E5-4B44-98A1-F6056D0EFF89Q39244725-841DD7C3-EE6A-48DD-8C0D-5F03776BF35FQ39357637-470A0ECC-1DC2-4A4C-AB32-3427893ED287Q39787520-F088C268-9ADA-45B5-BF9E-A040E0C9589FQ42772702-7909DE6C-E648-4254-9BCB-82B2BC35286BQ47398540-08F5D7C0-E297-42CC-957B-762E948E2D29
P2860
Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability
@en
type
label
Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability
@en
prefLabel
Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability
@en
P2860
P356
P1476
Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability
@en
P2093
A-Young Lee
Cheng-Ming Chiang
P2860
P304
P356
10.1074/JBC.M805835200
P407
P577
2008-11-26T00:00:00Z