Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits.
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A novel mutation in the switch 3 region of Gsalpha in a patient with Albright hereditary osteodystrophy impairs GDP binding and receptor activationSlow modal gating of single G protein-activated K+ channels expressed in Xenopus oocytesKir3 channel signaling complexes: focus on opioid receptor signalingModulation of rat cardiac sodium channel by the stimulatory G protein alpha subunitSignal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channelIdentification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinaseReceptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves G(alpha)q family subunits, phospholipase C, and a readily diffusible messenger.Modulation of midbrain dopamine neurotransmission by serotonin, a versatile interaction between neurotransmitters and significance for antipsychotic drug action.Antagonists of the receptor-G protein interface block Gi-coupled signal transduction.G-protein mediated gating of inward-rectifier K+ channels.Single channel analysis of the regulation of GIRK1/GIRK4 channels by protein phosphorylation.Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayersMechanisms of modulation of voltage-dependent calcium channels by G proteins.Substitutions in the pheromone-responsive Gbeta protein of Saccharomyces cerevisiae confer a defect in recovery from pheromone treatment.Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein alpha-subunit with impaired receptor-mediated activation because of elevated GTPase activity.Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunitsGIRK1 immunoreactivity is present predominantly in dendrites, dendritic spines, and somata in the CA1 region of the hippocampus.gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells.Heterologous facilitation of G protein-activated K(+) channels by beta-adrenergic stimulation via cAMP-dependent protein kinaseRGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels.Abscisic acid regulation of guard-cell K+ and anion channels in Gbeta- and RGS-deficient Arabidopsis linesThe role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel.Dissection of the calcium channel domains responsible for modulation of neuronal voltage-dependent calcium channels by G proteins.New roles for RGS2, 5 and 8 on the ratio-dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes.Regulation of cardiac L-type Ca2+ channel by coexpression of G(alpha s) in Xenopus oocytes.Mutagenesis of the conserved residue Glu259 of Gsalpha demonstrates the importance of interactions between switches 2 and 3 for activation.Gating properties of GIRK channels activated by Galpha(o)- and Galpha(i)-coupled muscarinic m2 receptors in Xenopus oocytes: the role of receptor precoupling in RGS modulation.Amplitude histogram-based method of analysis of patch clamp recordings that involve extreme changes in channel activity levels.Interaction sites of the G protein beta subunit with brain G protein-coupled inward rectifier K+ channel.Importance of the G protein gamma subunit in activating G protein-coupled inward rectifier K(+) channels.Direct activation of trpl cation channels by G alpha11 subunits.Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes.Heterologous expression and coupling of G protein-gated inwardly rectifying K+ channels in adult rat sympathetic neurons.Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K(+) channel and control regulation of RGS7 by G beta 5.Multiple pertussis toxin-sensitive G-proteins can couple receptors to GIRK channels in rat sympathetic neurons when expressed heterologously, but only native G(i)-proteins do so in situ.Inhibition of G-protein-coupled inward rectifying K+ channels by intracellular acidosis.Multiple neuropeptide Y receptors regulate K+ and Ca2+ channels in acutely isolated neurons from the rat arcuate nucleus.
P2860
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P2860
Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits.
@en
type
label
Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits.
@en
prefLabel
Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits.
@en
P2093
P50
P356
P1433
P1476
Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits
@en
P2093
Davidson N
Dessauer CW
Vorobiov D
P2888
P304
P356
10.1038/380624A0
P407
P577
1996-04-01T00:00:00Z
P5875
P6179
1030830363