Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.
about
Protein folding and quality control in the ERThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologySec61p is part of the endoplasmic reticulum-associated degradation machineryAutoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy.Yos9p assists in the degradation of certain nonglycosylated proteins from the endoplasmic reticulumRetrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p.Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathwaysAn improved reversibly dimerizing mutant of the FK506-binding protein FKBPStringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates.Interplay of substrate retention and export signals in endoplasmic reticulum quality control.N-terminal acetylation inhibits protein targeting to the endoplasmic reticulumSecretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting.Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation.Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems.Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope.A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer.Rkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins.Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.The endoplasmic reticulum-associated degradation pathways of budding yeast.Importin-4 Regulates Gene Delivery by Enhancing Nuclear Retention and Chromatin Deposition by Polyplexes.ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum.Making new out of old: recycling and modification of an ancient protein translocation system during eukaryotic evolution. Mechanistic comparison and phylogenetic analysis of ERAD, SELMA and the peroxisomal importomer.The Gp78 ubiquitin ligase: probing endoplasmic reticulum complexity.Gaucher disease paradigm: from ERAD to comorbidity.Specificity and regulation of the endoplasmic reticulum-associated degradation machinery.Three old and one new: protein import into red algal-derived plastids surrounded by four membranes.Quality control: ER-associated degradation: protein quality control and beyondEeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum.Heterologous expression of peptidyl-Lys metallopeptidase of Armillaria mellea and mutagenic analysis of the recombinant peptidase.The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane ProteinA component of the Sec61 ER protein transporting pore is required for plant susceptibility to powdery mildew.Defective ER associated degradation of a model luminal substrate in yeast carrying a mutation in the 4th ER luminal loop of Sec61p.An improved secretion signal enhances the secretion of model proteins from Pichia pastoris
P2860
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P2860
Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Sec61p is required for ERAD-L: ...... sing novel derivatives of CPY.
@en
type
label
Sec61p is required for ERAD-L: ...... sing novel derivatives of CPY.
@en
prefLabel
Sec61p is required for ERAD-L: ...... sing novel derivatives of CPY.
@en
P2093
P2860
P356
P1476
Sec61p is required for ERAD-L: ...... sing novel derivatives of CPY.
@en
P2093
Colin J Stirling
Gabriella M A Forte
Martin Willer
P2860
P304
33883-33888
P356
10.1074/JBC.M803054200
P407
P577
2008-09-25T00:00:00Z