New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 - Wikidata - wikimedia - TriplyDB

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

http://www.wikidata.org/entity/Q38432775

about

Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging.Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells.Cellular Senescence: A Translational Perspective.The Clinical Potential of Senolytic Drugs.Identification of HSP90 inhibitors as a novel class of senolytics.p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells.The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy.HIV as a Cause of Immune Activation and Immunosenescence.Mechanisms and Consequences of Oxidative Stress in Lung Disease: Therapeutic Implications for an Aging Populace.Cellular senescence in the aging and diseased kidney.Vascular Senescence in Cardiovascular and Metabolic Diseases.Association of chronic fatigue syndrome with premature telomere attrition.Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy.Strategies targeting cellular senescence.Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis.Blocking negative effects of senescence in human skin fibroblasts with a plant extract.Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype.Effects of senolytic drugs on human mesenchymal stromal cells.Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review.Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy.The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells Targeting senescence to delay progression of multiple sclerosis Ageing, Cellular Senescence and Neurodegenerative Disease

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P2860

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

http://www.wikidata.org/entity/Q38432775

description

2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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New agents that target senesce ...... ibitors, A1331852 and A1155463

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New agents that target senesce ...... ibitors, A1331852 and A1155463

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New agents that target senesce ...... ibitors, A1331852 and A1155463

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New agents that target senesce ...... ibitors, A1331852 and A1155463

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Ewald J Doornebal

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Heike Fuhrmann-Stroissnigg

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James L Kirkland

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Laura J Niedernhofer

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Mark Wentworth

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Nino Giorgadze

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Paul D Robbins

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Tamar Pirtskhalava

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Tamara Tchkonia

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Yi Zhu

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P2860

Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-κB activation and antioxidant defence

Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes

Fisetin: a dietary antioxidant for health promotion

Mechanisms and metabolic implications of regional differences among fat depots

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes.

Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms.

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

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955-963

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10.18632/AGING.101202

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3

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9

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5391241

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