Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
about
Mitochondria, cholesterol and cancer cell metabolismMitochondria in Cancer Energy Metabolism: Culprits or Bystanders?The sweet trap in tumors: aerobic glycolysis and potential targets for therapyMYC, Metabolism, and CancerReexamining cancer metabolism: Lactate production for carcinogenesis could be the purpose and explanation of the Warburg effectAdipose tissue dysfunction and its effects on tumor metabolismHypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symportersKinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling PathwayLactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector FunctionsLactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent MannerA Pilot Proteogenomic Study with Data Integration Identifies MCT1 and GLUT1 as Prognostic Markers in Lung AdenocarcinomaTargeting MYC Dependence by Metabolic Inhibitors in CancerCRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement.Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cellsCell surface lactate receptor GPR81 is crucial for cancer cell survival.The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.Monocarboxylate transporter 1 inhibitors as potential anticancer agentsMCT1 promotes the cisplatin-resistance by antagonizing Fas in epithelial ovarian cancer.Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts.Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.Targeting lactate transport suppresses in vivo breast tumour growthMitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer.Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction.MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.Hypothesis: solid tumours behave as systemic metabolic dictators.Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitorsMonocarboxylate transporters in the brain and in cancer.Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer.Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function.Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.Preparation of tetrasubstituted pyrimido[4,5-d]pyrimidine diones.Synthesis and Cytoxicity of Sempervirine and Analogues.One-pot directed alkylation/deprotection strategy for the synthesis of substituted pyrrole[3,4-d]pyridazinones.Metabolic control of signalling pathways and metabolic auto-regulation.Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors.The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agentsHypoxia and cellular metabolism in tumour pathophysiology.
P2860
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P2860
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Blocking lactate export by inh ...... sis and glutathione synthesis.
@en
type
label
Blocking lactate export by inh ...... sis and glutathione synthesis.
@en
prefLabel
Blocking lactate export by inh ...... sis and glutathione synthesis.
@en
P2093
P2860
P50
P1433
P1476
Blocking lactate export by inh ...... ysis and glutathione synthesis
@en
P2093
Andrea T Hooper
Andrew A Butler
Chunying Yang
Fangzheng Li
Heide Marika Genau
Jitendra K Mishra
John L Cleveland
K Ganesh Kumar
Keziban Unsal-Kacmaz
Kristen E N Scott
P2860
P304
P356
10.1158/0008-5472.CAN-13-2034
P407
P577
2013-11-27T00:00:00Z