about
Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced ActivityMolecular chaperones: guardians of the proteome in normal and disease statesContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisAsymmetry in the function and dynamics of the cytosolic group II chaperonin CCT/TRiCStructural insight into the cooperation of chloroplast chaperonin subunits.Characterization of group II chaperonins from an acidothermophilic archaeon Picrophilus torridus.Expression and diagnostic value of CCT3 and IQGAP3 in hepatocellular carcinoma.E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response.Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.Cellular Proteomes Drive Tissue-Specific Regulation of the Heat Shock Response.Protein Quality Control by Molecular Chaperones in Neurodegeneration.Internal (His)₆-tagging delivers a fully functional hetero-oligomeric class II chaperonin in high yield.Chaperone-client interactions: Non-specificity engenders multifunctionality.Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasisReplacement of GroEL in Escherichia coli by the Group II Chaperonin from the Archaeon Methanococcus maripaludis.Differential conformational modulations of MreB folding upon interactions with GroEL/ES and TRiC chaperonin components.Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes.An information theoretic framework reveals a tunable allosteric network in group II chaperonins.A systematic atlas of chaperome deregulation topologies across the human cancer landscape.Intraring allostery controls the function and assembly of a hetero-oligomeric class II chaperonin.Pathways of cellular proteostasis in aging and disease.Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells.Large-scale aggregation analysis of eukaryotic proteins reveals an involvement of intrinsically disordered regions in protein folding.Genetic expansion of chaperonin-containing TCP-1 (CCT/TRiC) complex subunits yields testis-specific isoforms required for spermatogenesis in planarian flatworms.Vacuolar ATPase as a possible therapeutic target in human acute myeloid leukemia.Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth.Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis.Chloroplast Chaperonin: An Intricate Protein Folding Machine for Photosynthesis.GroEL and the GroEL-GroES Complex.Insights into the ubiquitin-proteasome system of human embryonic stem cells.Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog.Single-Ring Intermediates Are Essential for Some Chaperonins.Structural investigation of a chaperonin in action reveals how nucleotide binding regulates the functional cycleThe CCT chaperonin is a novel regulator of Ca signaling through modulation of Orai1 traffickingThe ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The Mechanism and Function of Group II Chaperonins.
@en
type
label
The Mechanism and Function of Group II Chaperonins.
@en
prefLabel
The Mechanism and Function of Group II Chaperonins.
@en
P2860
P1476
The Mechanism and Function of Group II Chaperonins.
@en
P2093
Kevin Dalton
P2860
P304
P356
10.1016/J.JMB.2015.04.013
P407
P577
2015-04-29T00:00:00Z