Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade.
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Signaling Pathways in Osteoclast DifferentiationInvolvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts.Strontium-loaded titania nanotube arrays repress osteoclast differentiation through multiple signalling pathways: In vitro and in vivo studiesA FKBP5 mutation is associated with Paget's disease of bone and enhances osteoclastogenesis.Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced OsteoporosisIn Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro.PKCβ positively regulates RANKL-induced osteoclastogenesis by inactivating GSK-3β.Dual Effect of Chrysanthemum indicum Extract to Stimulate Osteoblast Differentiation and Inhibit Osteoclast Formation and Resorption In VitroSelective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy.Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation.AKT Pathway Affects Bone Regeneration in Nonunion Treated with Umbilical Cord-Derived Mesenchymal Stem Cells.Ethanolic extract of Schizonepeta tenuifolia attenuates osteoclast formation and activation in vitro and protects against lipopolysaccharide-induced bone loss in vivo.NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-N:B and Reactive Oxygen Species Pathways.Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation.ADP-Ribosylation Factor 1 Regulates Proliferation, Migration, and Fusion in Early Stage of Osteoclast DifferentiationIL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1).Ebselen Is a Potential Anti-Osteoporosis Agent by Suppressing Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Osteoclast Differentiation In vitro and Lipopolysaccharide-Induced Inflammatory Bone Destruction In vivoCaffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks.Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway.RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα.Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation in vitro.Methyl Gallate Inhibits Osteoclast Formation and Function by Suppressing Akt and Btk-PLCγ2-Ca2+ Signaling and Prevents Lipopolysaccharide-Induced Bone Loss.Signaling pathways affecting skeletal health.Modulation of macrophage activation and programming in immunity.Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies.The protein kinase 2 inhibitor CX-4945 regulates osteoclast and osteoblast differentiation in vitro.Staphylococcus aureus Protein A induces osteoclastogenesis via the NF‑κB signaling pathway.Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells.Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signalingThe blocking of uPAR suppresses lipopolysaccharide-induced inflammatory osteoclastogenesis and the resultant bone loss through attenuation of integrin β3/Akt pathwayuPA-derived peptide, Å6 is involved in the suppression of lipopolysaccaride-promoted inflammatory osteoclastogenesis and the resultant bone loss.Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities.Staphylococcus Aureus Induces Osteoclastogenesis via the NF-κB Signaling Pathway.Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells.Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation.17β-estradiol attenuates homocysteine-induced oxidative stress and inflammatory response as well as MAPKs cascade via activating PI3-K/Akt signal transduction pathway in Raw 264.7 cells.Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation.Resveratrol prevents osteoporosis by upregulating FoxO1 transcriptional activity.Dendrobium officinale Orchid Extract Prevents Ovariectomy-Induced Osteoporosis in Vivo and Inhibits RANKL-Induced Osteoclast Differentiation in Vitro.Gα12 regulates osteoclastogenesis by modulating NFATc1 expression.
P2860
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P2860
Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Akt induces osteoclast differe ...... SK3β/NFATc1 signaling cascade.
@en
type
label
Akt induces osteoclast differe ...... SK3β/NFATc1 signaling cascade.
@en
prefLabel
Akt induces osteoclast differe ...... SK3β/NFATc1 signaling cascade.
@en
P2093
P356
P1476
Akt induces osteoclast differe ...... SK3β/NFATc1 signaling cascade.
@en
P2093
Bang Ung Youn
Jang Bae Moon
Jung Ha Kim
Kabsun Kim
Nacksung Kim
Soo Young Lee
P304
P356
10.4049/JIMMUNOL.1101254
P407
P577
2011-11-30T00:00:00Z