about
The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevisHistone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeastSpreading of transcriptional repressor SIR3 from telomeric heterochromatinNuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1.Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer.Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing.The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expressionIntrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression.Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors.Trans-repression of beta-catenin activity by nuclear receptors.Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro.SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer.Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin.Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions.Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genes.Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes.SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells.Analysis of regulatory elements of E-cadherin with reporter gene constructs in transgenic mouse embryos.Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures.Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics.Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways.E-cadherin intron 2 contains cis-regulatory elements essential for gene expression.Mediator is a transducer of Wnt/beta-catenin signaling.Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction.Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer.Rat antibodies as probes for the characterization of progesterone receptor A and B proteins from laying hen oviduct cytosolInhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosisLoss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cellsGenome-wide mapping of DNA-binding sites identifies stemness-related genes as directly repressed targets of SNAIL1 in colorectal cancer cellsSNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation
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P50
description
celbioloog
@nl
hulumtues
@sq
researcher
@en
ricercatore
@it
հետազոտող
@hy
name
Andreas Hecht
@ast
Andreas Hecht
@en
Andreas Hecht
@es
أندرياس هيكت
@ar
type
label
Andreas Hecht
@ast
Andreas Hecht
@en
Andreas Hecht
@es
أندرياس هيكت
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prefLabel
Andreas Hecht
@ast
Andreas Hecht
@en
Andreas Hecht
@es
أندرياس هيكت
@ar
P214
P227
P1153
7102106980
P21
P214
P227
1076262384
P31
P496
0000-0003-2262-2575
P734
P735
P7859
viaf-317084221