TGFbeta1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function.

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Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis.Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice.

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P2860

TGFbeta1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function.

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2008 nî lūn-bûn

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TGFbeta1 deficiency does not a ...... d loss of regulatory function.

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TGFbeta1 deficiency does not a ...... d loss of regulatory function.

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George F Babcock

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Ram R Singh

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Ramireddy Bommireddy

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Thomas Doetschman

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P2860

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Control of regulatory T cell development by the transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes

CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.

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206-213

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scholarly article

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10.1016/J.CLIM.2007.12.008

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127

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18308639

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TGFbeta1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function.

about

P2860

P2860

TGFbeta1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function.

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