The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1.
about
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domainsSesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.Sestrin regulation of TORC1: Is Sestrin a leucine sensor?SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophagesStress management by autophagy: Implications for chemoresistance.Biochemical Basis of Sestrin Physiological Activities.Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4.TCS2 Increases Olaquindox-Induced Apoptosis by Upregulation of ROS Production and Downregulation of Autophagy in HEK293 Cells.Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress.Nrf2 at the Heart of Oxidative Stress and Cardiac Protection.Effects of spermine on the antioxidant status and gene expression of antioxidant-related signaling molecules in the liver and longissimus dorsi of piglets.Non-canonical activation of NRF2: New insights and its relevance to disease.Activation of Nrf2 signaling by natural products-can it alleviate diabetes?Sestrin 2 attenuates neonatal rat cardiomyocyte hypertrophy induced by phenylephrine via inhibiting ERK1/2.SESN2 negatively regulates cell proliferation and casein synthesis by inhibition the amino acid-mediated mTORC1 pathway in cow mammary epithelial cells.
P2860
Q28114865-D8FE4E1A-EEF2-451A-9A4E-202C539F3F66Q30354894-E1C35938-ADD7-4C7C-AB74-4081EE8BD794Q36197351-BD068077-B605-48DD-AC25-A1A05B929633Q36992443-46AB7F43-A9FA-408E-AD26-4B49666C65F2Q37141778-EEAC66EB-D06D-4EA5-BEF8-870C5C4765CAQ38693407-99BAFAD8-21E3-441D-97F2-FF4EF4D490F8Q38833370-190804E6-C63D-4522-8186-CEBE12C01D1EQ39987357-4A82DF73-1D39-4E48-AAA5-55BA3D0DFB71Q46388245-842C46E3-FE2A-4CCE-A149-ADEAD419A184Q46597399-5941315B-3C91-4203-AD95-AD8FAF7A4594Q47350229-204394E1-35D0-4163-9C90-04FF6732E1FCQ47609311-D6F2AC30-1677-43C5-8803-F638BBC8A653Q47870645-A596787C-C2E2-4268-B475-D29C316D930EQ49385295-2AF7A359-A6A5-49AF-AC91-9EACDE6882F6Q51006793-38BE8AA0-2694-4977-80D4-A7CD61C35747Q52368871-337F2F2F-7B99-4D85-9A5C-2E99146A46E7
P2860
The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The antioxidant function of se ...... n and by inhibition of mTORC1.
@en
type
label
The antioxidant function of se ...... n and by inhibition of mTORC1.
@en
prefLabel
The antioxidant function of se ...... n and by inhibition of mTORC1.
@en
P1476
The antioxidant function of se ...... on and by inhibition of mTORC1
@en
P2093
Sue Goo Rhee
P304
P356
10.1016/J.FREERADBIOMED.2015.06.007
P50
P577
2015-06-25T00:00:00Z