Progeria, rapamycin and normal aging: recent breakthrough.
about
Advances in targeting signal transduction pathwaysPotential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseasesCreatine protects against excitoxicity in an in vitro model of neurodegenerationOxidative stress and antioxidant response in fibroblasts from Werner and atypical Werner syndromes.Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cellHP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells.Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescenceSignaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cellsAutomated image analysis of nuclear shape: what can we learn from a prematurely aged cell?Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drugA filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction.The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats.Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberineModeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells.Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metforminMTOR-driven quasi-programmed aging as a disposable soma theory: blind watchmaker vs. intelligent designer.Mechanisms of radiation toxicity in transformed and non-transformed cellsManagement of multicellular senescence and oxidative stress.Progeroid laminopathy with restrictive dermopathy-like features caused by an isodisomic LMNA mutation p.R435C.A novel immunomodulatory molecularly targeted strategy for refractory Hodgkin's lymphomaFunctional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands.The Intricate Interplay between Mechanisms Underlying Aging and Cancer.mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated agingmTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cellsDeciphering the role of nuclear factor-κB in cellular senescence.Macrolide therapy in chronic inflammatory diseases.Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.
P2860
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P2860
Progeria, rapamycin and normal aging: recent breakthrough.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Progeria, rapamycin and normal aging: recent breakthrough.
@en
type
label
Progeria, rapamycin and normal aging: recent breakthrough.
@en
prefLabel
Progeria, rapamycin and normal aging: recent breakthrough.
@en
P2860
P356
P1433
P1476
Progeria, rapamycin and normal aging: recent breakthrough.
@en
P2860
P304
P356
10.18632/AGING.100352
P577
2011-07-01T00:00:00Z