EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks.
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Preclinical Data on Efficacy of 10 Drug-Radiation Combinations: Evaluations, Concerns, and RecommendationsLung cancer cells that survive ionizing radiation show increased integrin α2β1- and EGFR-dependent invasivenessLung Cancer Gene Signatures and Clinical PerspectivesPostoperative chemoradiotherapy and cetuximab for high-risk squamous cell carcinoma of the head and neck: Radiation Therapy Oncology Group RTOG-0234A phase I study of concurrent individualized, isotoxic accelerated radiotherapy and cisplatin-vinorelbine-cetuximab in patients with stage III non-small-cell lung cancer.EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage.EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation.Feasibility of cetuximab and chemoradiotherapy combination in Chinese patients with unresectable stage III non-small cell lung cancer: a preliminary reportAdding Erlotinib to Chemoradiation Improves Overall Survival but Not Progression-Free Survival in Stage III Non-Small Cell Lung CancerDNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity.Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck.Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells.Torin2 Suppresses Ionizing Radiation-Induced DNA Damage RepairEGFR inhibition in non-small cell lung cancer: current evidence and future directionsRhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines.Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair.A review of clinical trials of cetuximab combined with radiotherapy for non-small cell lung cancerNew insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy.Reversion of the ErbB malignant phenotype and the DNA damage response.Ionizing radiation-induced responses in human cells with differing TP53 status.Impact of Premature Senescence on Radiosensitivity Measured by High Throughput Cell-Based Assays.Multinucleated Giant Cancer Cells Produced in Response to Ionizing Radiation Retain Viability and Replicate Their Genome.The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to γ-rays and/or erlotinib.Molecular Targeting of Growth Factor Receptor Signaling in Radiation Oncology.Spontaneous γH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression.Integration of Stereotactic Body Radiation Therapy With Tyrosine Kinase Inhibitors in Stage IV Oncogene-Driven Lung CancerAdapting a drug screening platform to discover associations of molecular targeted radiosensitizers with genomic biomarkersSpatial and temporal distribution of γH2AX fluorescence in human cell cultures following synchrotron-generated X-ray microbeams: lack of correlation between persistent γH2AX foci and apoptosis.The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.The radiosensitizing effect of the aurora kinase inhibitors, ENMD-2076, on canine mast cell tumours in vitro.Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway.Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome.Cellular and molecular properties of (90)Y-labeled cetuximab in combination with radiotherapy on human tumor cells in vitro.Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests.Mechanisms of skin aging induced by EGFR inhibitors.Nimotuzumab enhances radiation sensitivity of NSCLC H292 cells in vitro by blocking epidermal growth factor receptor nuclear translocation and inhibiting radiation-induced DNA damage repairMeeting report: Signal transduction meets systems biology.Microwave ablation combined with EGFR-TKIs versus only EGFR-TKIs in advanced NSCLC patients with EGFR-sensitive mutations.Aldosterone induces p21-regulated apoptosis via increased synthesis and secretion of tumour necrosis factor-α in human proximal tubular cells.
P2860
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P2860
EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
EGF receptor inhibition radios ...... ning DNA double-strand breaks.
@en
type
label
EGF receptor inhibition radios ...... ning DNA double-strand breaks.
@en
prefLabel
EGF receptor inhibition radios ...... ning DNA double-strand breaks.
@en
P2093
P2860
P1433
P1476
EGF receptor inhibition radios ...... ning DNA double-strand breaks.
@en
P2093
Akash Nanda
Cyril Benes
David Sander
Ekkehard Dikomey
Fabian Morsbach
Henning Willers
Jeffrey Settleman
Jochen Dahm-Daphi
Liliana Gheorghiu
Malte Kriegs
P2860
P304
P356
10.1158/0008-5472.CAN-11-0213
P407
P577
2011-08-18T00:00:00Z