Biochemistry of altered brain proteins in Alzheimer's disease.
about
Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugsAdvancing translational research with the Semantic WebTau protein kinase I is essential for amyloid beta-protein-induced neurotoxicitypH-dependent structural transitions of Alzheimer amyloid peptides.Hypothesis: microtubules, a key to Alzheimer diseaseThe expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter.A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice.Molecular features of hypothalamic plaques in Alzheimer's disease.Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.Molecular biology and transgenetics of prion diseases.Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease.Amyloid-β Peptides and Tau Protein as Biomarkers in Cerebrospinal and Interstitial Fluid Following Traumatic Brain Injury: A Review of Experimental and Clinical Studies.Beta-amyloid precursor protein cleavage by a membrane-bound protease.Amyloid precursor protein in aged nonhuman primates.Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.Mouse models of Alzheimer's disease.Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and NeurotoxicityBrain parenchymal and microvascular amyloid in Alzheimer's disease.Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice.Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques.Binding of amyloid beta-peptide to ganglioside micelles is dependent on histidine-13.Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdownNeurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid beta-protein of Alzheimer's disease.Immunochemical demonstration of tropomyosin in the neurofibrillary pathology of Alzheimer's disease.New drug discovery for Alzheimer's disease: Challenges and hopes.Analysis of mouse intron 7 DNA sequence of the APP gene: comparison with the human homologue.Differing effects of toxicants (methylmercury, inorganic mercury, lead, amyloid β, and rotenone) on cultured rat cerebrocortical neurons: differential expression of rho proteins associated with neurotoxicity.Alzheimer's disease and the beta amyloid gene.In vivo conversion of racemized beta-amyloid ([D-Ser 26]A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients.Beta-amyloid racemized at the Ser26 residue in the brains of patients with Alzheimer disease: implications in the pathogenesis of Alzheimer disease.The acute neurotoxic effect of beta-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F.Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells.Amyloidogenicity of rodent and human beta A4 sequences.Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease.Protein TAU variants present in paired helical filaments (PHFs) of Alzheimer brains.Self-oligomerization of NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer's disease amyloid, observed in the presence of a C-terminal A beta fragment (residues 25-35).Does the Kunitz domain from the Alzheimer's amyloid beta protein precursor inhibit a kallikrein responsible for post-translational processing of nerve growth factor precursor?
P2860
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P2860
Biochemistry of altered brain proteins in Alzheimer's disease.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Biochemistry of altered brain proteins in Alzheimer's disease.
@en
type
label
Biochemistry of altered brain proteins in Alzheimer's disease.
@en
prefLabel
Biochemistry of altered brain proteins in Alzheimer's disease.
@en
P1476
Biochemistry of altered brain proteins in Alzheimer's disease.
@en
P2093
P304
P356
10.1146/ANNUREV.NE.12.030189.002335
P577
1989-01-01T00:00:00Z