Resistance of human immunodeficiency virus type 1 to a third-generation fusion inhibitor requires multiple mutations in gp41 and is accompanied by a dramatic loss of gp41 function
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Viral quasispecies evolutionThe M-T Hook Structure Is Critical for Design of HIV-1 Fusion InhibitorsStructural Basis of Potent and Broad HIV-1 Fusion Inhibitor CP32MThe Low-Cost Compound Lignosulfonic Acid (LA) Exhibits Broad-Spectrum Anti-HIV and Anti-HSV Activity and Has Potential for Microbicidal ApplicationsTwo M-T hook residues greatly improve the antiviral activity and resistance profile of the HIV-1 fusion inhibitor SC29EK.Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide designResistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics.HIV takes double hit before entryMechanism of HIV-1 Resistance to Short-Peptide Fusion Inhibitors Targeting the Gp41 PocketGenetic Pathway of HIV-1 Resistance to Novel Fusion Inhibitors Targeting the Gp41 Pocket.A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains.Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strainsCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors.Molecular determinants defining the triggering range of prefusion F complexes of canine distemper virusEscape from human immunodeficiency virus type 1 (HIV-1) entry inhibitors.Increased replicative fitness can lead to decreased drug sensitivity of hepatitis C virus.The impact of HIV-1 genetic diversity on the efficacy of a combinatorial RNAi-based gene therapy.HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein SpikeHIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions.The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance.Design of a modular tetrameric scaffold for the synthesis of membrane-localized D-peptide inhibitors of HIV-1 entry.Adding an Artificial Tail-Anchor to a Peptide-Based HIV-1 Fusion Inhibitor for Improvement of Its Potency and Resistance Profile.Mechanism of HIV-1 Resistance to an Electronically Constrained α-Helical Peptide Membrane Fusion Inhibitor.Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket.A Novel gp41-Binding Adnectin with Potent Anti-HIV Activity Is Highly Synergistic when Linked to a CD4-Binding Adnectin.HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins
P2860
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P2860
Resistance of human immunodeficiency virus type 1 to a third-generation fusion inhibitor requires multiple mutations in gp41 and is accompanied by a dramatic loss of gp41 function
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Resistance of human immunodefi ...... dramatic loss of gp41 function
@en
type
label
Resistance of human immunodefi ...... dramatic loss of gp41 function
@en
prefLabel
Resistance of human immunodefi ...... dramatic loss of gp41 function
@en
P2093
P2860
P356
P1433
P1476
Resistance of human immunodefi ...... dramatic loss of gp41 function
@en
P2093
Ben Berkhout
Dirk Eggink
Ilja Bontjer
Johannes P M Langedijk
Rogier W Sanders
P2860
P304
10785-10797
P356
10.1128/JVI.05331-11
P407
P577
2011-08-10T00:00:00Z