about
The epidermal barrier function is dependent on the serine protease CAP1/Prss8Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models.Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistanceChemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation.A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis.The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes.Overview of Genetically Engineered Mouse Models of Papillary and Anaplastic Thyroid Cancers: Enabling Translational Biology for Patient Care Improvement.Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method.E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor.Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis.Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import.Conditional gene targeting of the ENaC subunit genes Scnn1b and Scnn1g.Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function.PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors.The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse modelThe L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer.MEK Inhibition Induces Therapeutic Iodine Uptake in a Murine Model of Anaplastic Thyroid Cancer
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description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
Roch-Philippe Charles
@ast
Roch-Philippe Charles
@en
Roch-Philippe Charles
@es
Roch-Philippe Charles
@nl
Roch-Philippe Charles
@sl
type
label
Roch-Philippe Charles
@ast
Roch-Philippe Charles
@en
Roch-Philippe Charles
@es
Roch-Philippe Charles
@nl
Roch-Philippe Charles
@sl
prefLabel
Roch-Philippe Charles
@ast
Roch-Philippe Charles
@en
Roch-Philippe Charles
@es
Roch-Philippe Charles
@nl
Roch-Philippe Charles
@sl
P106
P21
P31
P496
0000-0002-5243-3866