Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.
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Wnt Signaling in Cancer Stem Cell BiologySimilar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistanceDefining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathwaysHeterogeneity of the level of activity of lgr5+ intestinal stem cellsStem cell competition in the gut: insights from multi-scale computational modellingCoalescent models for developmental biology and the spatio-temporal dynamics of growing tissues.Quantification of crypt and stem cell evolution in the normal and neoplastic human colonImpact of genomic damage and ageing on stem cell functionThe evolutionary trade-off between stem cell niche size, aging, and tumorigenesis.Basolateral junction proteins regulate competition for the follicle stem cell niche in the Drosophila ovary.Neutral Competition for Drosophila Follicle and Cyst Stem Cell Niches Requires Vesicle Trafficking GenesMapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP alleleEmerging understanding of multiscale tumor heterogeneityBrainbow: new resources and emerging biological applications for multicolor genetic labeling and analysisThe molecular clock of neutral evolution can be accelerated or slowed by asymmetric spatial structure.Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila TestisCell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent MannerTargeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cellsMathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer.Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.Quantifying Lgr5-positive stem cell behaviour in the pyloric epithelium.Cell Competition Drives the Growth of Intestinal Adenomas in Drosophila.Sporadic colorectal cancer: Studying ways to an end.The implications of small stem cell niche sizes and the distribution of fitness effects of new mutations in aging and tumorigenesis.Defining the clonal dynamics leading to mouse skin tumour initiation.Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation.Thyroid hormones and their nuclear receptors: new players in intestinal epithelium stem cell biology?Mutation, clonal fitness and field change in epithelial carcinogenesis.Stem vs non-stem cell origin of colorectal cancer.Somatic mutation in cancer and normal cells.Adult stem cell lineage tracing and deep tissue imaging.Stem cells and healthy aging.Clonal Evolution of Stem Cells in the Gastrointestinal Tract.Clonal evolution of colorectal cancer in IBD.The Barrett's Gland in Phenotype Space.Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.Myo-inositol reduces β-catenin activation in colitis.An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium.Notch signaling regulates gastric antral LGR5 stem cell function.
P2860
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P2860
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
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2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
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2013年學術文章
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name
Biased competition between Lgr ...... tion induces clonal expansion.
@en
type
label
Biased competition between Lgr ...... tion induces clonal expansion.
@en
prefLabel
Biased competition between Lgr ...... tion induces clonal expansion.
@en
P2093
P2860
P356
P1433
P1476
Biased competition between Lgr ...... ation induces clonal expansion
@en
P2093
Arnout G Schepers
Hans Clevers
Johan H van Es
P2860
P356
10.1002/EMBR.201337799
P577
2013-12-15T00:00:00Z