Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization.
about
The Closing Mechanism of DNA Polymerase I at Atomic ResolutionAt the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?The glmS ribozyme: use of a small molecule coenzyme by a gene-regulatory RNAPolymerase-tailored variations in the water-mediated and substrate-assisted mechanism for nucleotidyl transfer: insights from a study of T7 DNA polymerase.Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion.Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase.Ultrafast water dynamics at the interface of the polymerase-DNA binding complexPrechemistry versus preorganization in DNA replication fidelity.Perspective: pre-chemistry conformational changes in DNA polymerase mechanismsComputational simulation strategies for analysis of multisubunit RNA polymerases.Direct probing of solvent accessibility and mobility at the binding interface of polymerase (Dpo4)-DNA complex.Why nature really chose phosphate.Applications of quantum mechanical/molecular mechanical methods to the chemical insertion step of DNA and RNA polymerization.Computational delineation of the catalytic step of a high-fidelity DNA polymerase.The EVB as a quantitative tool for formulating simulations and analyzing biological and chemical reactions.Exploring the mechanism of DNA polymerases by analyzing the effect of mutations of active site acidic groups in Polymerase βAddressing open questions about phosphate hydrolysis pathways by careful free energy mapping.Substrate-mediated proton relay mechanism for the religation reaction in topoisomerase II.Computational Simulations of DNA Polymerases: Detailed Insights on Structure/Function/Mechanism from Native Proteins to Cancer Variants.Computational Evaluation of Nucleotide Insertion Opposite Expanded and Widened DNA by the Translesion Synthesis Polymerase Dpo4.Prechemistry barriers and checkpoints do not contribute to fidelity and catalysis as long as they are not rate limiting
P2860
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P2860
Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Quantum mechanics/molecular me ...... or active site reorganization.
@en
type
label
Quantum mechanics/molecular me ...... or active site reorganization.
@en
prefLabel
Quantum mechanics/molecular me ...... or active site reorganization.
@en
P2860
P356
P1476
Quantum mechanics/molecular me ...... or active site reorganization.
@en
P2093
Tamar Schlick
Yanli Wang
P2860
P304
13240-13250
P356
10.1021/JA802215C
P407
P577
2008-09-12T00:00:00Z