IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice

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Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias.Macrophage polarization and allergic asthma.Dual role of YM1+ M2 macrophages in allergic lung inflammation.

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IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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IRF5 distinguishes severe asth ...... airway hyperreactivity in mice

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IRF5 distinguishes severe asth ...... airway hyperreactivity in mice

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IRF5 distinguishes severe asth ...... airway hyperreactivity in mice

@en

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IRF5 distinguishes severe asth ...... airway hyperreactivity in mice

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Anuradha Ray

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Christina Morse

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Kathryn L Scholl

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Krishnendu Chakraborty

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Mahesh Raundhal

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Prabir Ray

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Rachael E Huff

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Rachel Hannum

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Sally E Wenzel

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Seyed M Nouraie

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Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

Cyclic di-GMP sensing via the innate immune signaling protein STING

Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

STING is a direct innate immune sensor of cyclic di-GMP

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

STING: infection, inflammation and cancer

Regulating the adaptive immune response to respiratory virus infection

Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses.

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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scholarly article

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10.1172/JCI.INSIGHT.91019

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Marc Gauthier

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2017-05-18T00:00:00Z

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28515358

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5436536

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IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice

about

P2860

P2860

IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice

description

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type

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P1433

P1476

P2093

P2860

P31

P356

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P31

P356

P433

P478

P50

P577

P698

P932