p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
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Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New TricksExpression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors.Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence.Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells.Effects of ageing and senescence on pancreatic β-cell function.Advances in β cell replacement and regeneration strategies for treating diabetesPancreas Volume and Fat Deposition in Diabetes and Normal Physiology: Consideration of the Interplay Between Endocrine and Exocrine PancreasHypoxia driven glycation: Mechanisms and therapeutic opportunities.Senescence in Health and Disease.Senescent cells: an emerging target for diseases of ageing.Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.Intrinsic Variability Present in Wharton's Jelly Mesenchymal Stem Cells and T Cell Responses May Impact Cell Therapy.Senescence in the aging process.P16 INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 DeficiencyHow stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?Interrogating islets in health and disease with single-cell technologiesDifferent developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth.Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.Cdkn2a deficiency promotes adipose tissue browning.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance.Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets.Senescence and aging: Causes, consequences, and therapeutic avenues.Cellular senescence: Implications for metabolic disease.Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system.Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence.β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance.Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes.Mechanisms and functions of cellular senescence.Strategies targeting cellular senescence.Senescent cells and osteoarthritis: a painful connection.T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells.Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailtyPancreas regeneration
P2860
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P2860
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
@en
type
label
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
@en
prefLabel
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
@en
P2093
P2860
P356
P1433
P1476
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion
@en
P2093
A M James Shapiro
Agnes Klochendler
Aharon Helman
Alvin C Powers
Amit Zamir
Avital Swisa
Chunhua Dai
Dorin Shreibman
Elad Horwitz
Ittai Ben-Porath
P2860
P2888
P304
P356
10.1038/NM.4054
P407
P577
2016-03-07T00:00:00Z