about
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genesA sustained dietary change increases epigenetic variation in isogenic miceNormalization and statistical analysis of quantitative proteomics data generated by metabolic labeling.Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expressionCell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenograftsImpaired B cell development in the absence of Krüppel-like factor 3.RON is not a prognostic marker for resectable pancreatic cancer.qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profilesELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticitySomatic point mutation calling in low cellularity tumors.PINA v2.0: mining interactome modules.MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor geneInheritance of coronary artery disease in men: an analysis of the role of the Y chromosome.The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.Whole genomes redefine the mutational landscape of pancreatic cancer.Whole-genome sequencing overcomes pseudogene homology to diagnose autosomal dominant polycystic kidney diseaseGenetic dissection of gene regulation in multiple mouse tissues.Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents.Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial α5 integrinIntra- and inter-individual genetic differences in gene expressionMaternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice.Clinical and molecular characterization of HER2 amplified-pancreatic cancer.Understanding pancreatic cancer genomes.Proteomic comparison of colorectal tumours and non-neoplastic mucosa from paired patient samples using iTRAQ mass spectrometry.Genomic analyses identify molecular subtypes of pancreatic cancer.JRK is a positive regulator of β-catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer.Gonadal mosaicism of a novel IQSEC2 variant causing female limited intellectual disability and epilepsy.Germline variants in familial pituitary tumour syndrome genes are common in young patients and families with additional endocrine tumours.c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer.Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater.Expression of pro- and antiapoptotic molecules of the Bcl-2 family in human islets postisolation.Asparagine Synthetase Deficiency causes reduced proliferation of cells under conditions of limited asparagine.SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.Defining the genetic basis of early onset hereditary spastic paraplegia using whole genome sequencingA SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders.A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis.Cold adaptation in the marine bacterium, Sphingopyxis alaskensis, assessed using quantitative proteomics.BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer.Human islets express a marked proinflammatory molecular signature prior to transplantation.
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Mark J. Cowley
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Mark J. Cowley
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Mark J. Cowley
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Mark J. Cowley
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Mark J. Cowley
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Mark J. Cowley
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Mark J. Cowley
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Mark J. Cowley
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Mark J. Cowley
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Mark J. Cowley
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0000-0002-9519-5714