about
Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.A fully humanized transgenic mouse model of Huntington disease.Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysisFull-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expressionDespite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosisEarly increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice.Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes.Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activityCleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's diseaseInhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle.Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-CardiomyocytesHistone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cellsDifferential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of diseaseReversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.Preclinical models: needed in translation? A Pro/Con debate.Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.A thiol probe for measuring unfolded protein load and proteostasis in cells.Mouse models of Huntington disease: variations on a theme.Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.Heritability of pain sensitivity and opioid analgesia.Polyglutamine diseases and the risk of cancer.NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease.Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease.Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease.A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles.Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease.Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice.Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice.House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation.Impact of cigarette smoke on clearance and inflammation after Pseudomonas aeruginosa infection.Concomitant airway expression of granulocyte-macrophage colony-stimulating factor and decorin, a natural inhibitor of transforming growth factor-beta, breaks established inhalation tolerance.Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
@en
հետազոտող
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name
Mahmoud A. Pouladi
@ast
Mahmoud A. Pouladi
@en
Mahmoud A. Pouladi
@es
Mahmoud A. Pouladi
@nl
Mahmoud A. Pouladi
@sl
type
label
Mahmoud A. Pouladi
@ast
Mahmoud A. Pouladi
@en
Mahmoud A. Pouladi
@es
Mahmoud A. Pouladi
@nl
Mahmoud A. Pouladi
@sl
prefLabel
Mahmoud A. Pouladi
@ast
Mahmoud A. Pouladi
@en
Mahmoud A. Pouladi
@es
Mahmoud A. Pouladi
@nl
Mahmoud A. Pouladi
@sl
P1053
B-8743-2016
P106
P1153
6507466238
P21
P2798
P31
P3829
P496
0000-0002-9030-0976