Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types.
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Wnt Signaling in Cancer Stem Cell BiologyControl of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in CancerFrizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat CancerR-Spondins Are Expressed by the Intestinal Stroma and are Differentially Regulated during Citrobacter rodentium- and DSS-Induced Colitis in Mice.Irradiation enhances susceptibility of tumor cells to the antitumor effects of TNF-α activated adipose derived mesenchymal stem cells in breast cancer model.Rspo2 suppresses CD36-mediated apoptosis in oxidized low density lipoprotein-induced macrophages.Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusionsClinical value of R-spondins in triple-negative and metaplastic breast cancers.Developing drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases.WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer.R-spondin 2 promotes proliferation and migration via the Wnt/β-catenin pathway in human hepatocellular carcinoma.RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.SATB2/β-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer.MicroRNA-182 downregulates Wnt/β-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9.RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations.C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt/β-catenin signaling in cells.A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.Stress Response Protein RBM3 Promotes the Development of Colitis-associated Cancer.PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review).Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapyGermline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging ConceptsR-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cellsRSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1
P2860
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P2860
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Therapeutic Targeting of Tumor ...... esis in Multiple Cancer Types.
@en
type
label
Therapeutic Targeting of Tumor ...... esis in Multiple Cancer Types.
@en
prefLabel
Therapeutic Targeting of Tumor ...... esis in Multiple Cancer Types.
@en
P2093
P1433
P1476
Therapeutic Targeting of Tumor ...... esis in Multiple Cancer Types.
@en
P2093
Andrew Lam
Ann M Kapoun
Austin Gurney
Belinda Cancilla
Cecile Chartier
Chris Bond
Cristina Dee-Hoskins
Fumiko Axelrod
Gilbert O'Young
Jalpa Shah
P304
P356
10.1158/0008-5472.CAN-15-0561
P407
P577
2015-12-30T00:00:00Z