Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.
about
Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders.Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screensMultidimensional chemical control of CRISPR-Cas9.Heroes of peer review: Hyongbum (Henry) KimInvestigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system.The Power of CRISPR-Cas9-Induced Genome Editing to Speed Up Plant Breeding.Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.The Power of Zebrafish in Personalised Medicine.CRISPR Editing Technology in Biological and Biomedical Investigation.Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis.Nucleosomes Selectively Inhibit Cas9 Off-target Activity at a Site Located at the Nucleosome Edge.CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes.Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing.Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective.CRISPR/Cas9: at the cutting edge of hepatology.Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells.CRISPR-Cas9 cleavage efficiency correlates strongly with target-sgRNA folding stability: from physical mechanism to off-target assessment.Cas9-catalyzed DNA Cleavage Generates Staggered Ends: Evidence from Molecular Dynamics Simulations.Genomic Amplifications Cause False Positives in CRISPR Screens.Highly efficient and precise base editing in discarded human tripronuclear embryos.Immunity to CRISPR Cas9 and Cas12a therapeutics.Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing.A machine learning approach for predicting CRISPR-Cas9 cleavage efficiencies and patterns underlying its mechanism of action.CRISPR-mediated isolation of specific megabase segments of genomic DNA.Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.Characterization of Gene Alterations following Editing of the β-Globin Gene Locus in Hematopoietic Stem/Progenitor Cells.Zucchini-dependent piRNA processing is triggered by recruitment to the cytoplasmic processing machinery.Structure and Dynamics of Cas9 HNH Domain Catalytic State.A Simple and Universal System for Gene Manipulation in Aspergillus fumigatus: In Vitro-Assembled Cas9-Guide RNA Ribonucleoproteins Coupled with Microhomology Repair Templates.Optimized guide RNA structure for genome editing via Cas9.Engineering the Delivery System for CRISPR-Based Genome Editing.Am I ready for CRISPR? A user's guide to genetic screens.Beyond editing to writing large genomes.Precise Editing at DNA Replication Forks Enables Multiplex Genome Engineering in Eukaryotes.From Reductionism to Holism: Toward a More Complete View of Development Through Genome Engineering.Class 2 CRISPR-Cas RNA-guided endonucleases: Swiss Army knives of genome editing.CRISPR/Cas9-Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development.Break Breast Cancer Addiction by CRISPR/Cas9 Genome Editing.Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes.
P2860
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P2860
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.
@en
type
label
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.
@en
prefLabel
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.
@en
P2860
P356
P1476
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.
@en
P2093
J Keith Joung
Shengdar Q Tsai
P2860
P2888
P304
P356
10.1038/NRG.2016.28
P577
2016-04-01T00:00:00Z
P6179
1010657174