A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds.
about
Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells.XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose.Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
P2860
A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds.
description
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name
A method for quantification of ...... clear Export (SINE) compounds.
@en
type
label
A method for quantification of ...... clear Export (SINE) compounds.
@en
prefLabel
A method for quantification of ...... clear Export (SINE) compounds.
@en
P2093
P2860
P356
P1433
P1476
A method for quantification of ...... clear Export (SINE) compounds.
@en
P2093
Boris Klebanov
Diego Del Alamo
Erkan Baloglu
Margaret Lee
Marsha L Crochiere
Michael Kauffman
Scott Donovan
Sharon Shacham
Yosef Landesman
P2860
P304
P356
10.18632/ONCOTARGET.6495
P407
P577
2015-12-07T00:00:00Z