Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax.
about
New investigational drugs with single-agent activity in multiple myelomaRational combination strategies to enhance venetoclax activity and overcome resistance in hematologic malignancies.Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells.Metabolic Links between Plasma Cell Survival, Secretion, and Stress.Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation.Development of GLUT4-selective antagonists for multiple myeloma therapy.Venetoclax Synergizes with Radiotherapy for Treatment of B-cell Lymphomas.Pathways and mechanisms of venetoclax resistance.The combination of a sphingosine kinase 2 inhibitor (ABC294640) and a Bcl-2 inhibitor (ABT-199) displays synergistic anti-myeloma effects in myeloma cells without a t(11;14) translocation.Metabolic Features of Multiple Myeloma.The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γThe metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targets
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P2860
Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Targeting glutamine metabolism ...... hetic lethality to venetoclax.
@en
type
label
Targeting glutamine metabolism ...... hetic lethality to venetoclax.
@en
prefLabel
Targeting glutamine metabolism ...... hetic lethality to venetoclax.
@en
P2093
P2860
P356
P1433
P1476
Targeting glutamine metabolism ...... hetic lethality to venetoclax.
@en
P2093
H E Von Hollen
M Shanmugam
S M Matulis
P2860
P2888
P304
P356
10.1038/ONC.2015.464
P407
P577
2015-12-07T00:00:00Z
P6179
1022674477