The Fanconi anaemia pathway: new players and new functions.
about
Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cellsA never-ending story: the steadily growing family of the FA and FA-like genesCRISPR/Cas9-Mediated Correction of the FANCD1 Gene in Primary Patient CellsTaking a Bad Turn: Compromised DNA Damage Response in LeukemiaRescue from replication stress during mitosis.The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2.Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.Maintenance of genome stability by Fanconi anemia proteins.Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention.LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA RepairFANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end.Biallelic inactivation of REV7 is associated with Fanconi anemia.HSP90 Shapes the Consequences of Human Genetic Variation.The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair.A role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites.SNM1B/Apollo in the DNA damage response and telomere maintenanceHow I manage patients with Fanconi anaemia.Mechanisms of DNA damage, repair, and mutagenesis.Recent advances in the study of immunodeficiency and DNA damage response.Emerging functions of the Fanconi anemia pathway at a glance.A strategy for molecular diagnostics of Fanconi anemia in Brazilian patients.Ubiquitination-Linked Phosphorylation of the FANCI S/TQ Cluster Contributes to Activation of the Fanconi Anemia I/D2 Complex.The Role of Pontin and Reptin in Cellular Physiology and Cancer Etiology.Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair.FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.Germline Mutations in Cancer Predisposition Genes are Frequent in Sporadic SarcomasBRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.V(D)J recombination process and the Pre-B to immature B-cells transition are altered in Fanca(-/-) mice.DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.CRISPR/Cas9 Targeted Gene Editing and Cellular Engineering in Fanconi Anemia.Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia.CD10-/ALDH- cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy.Bone Marrow Mesenchymal Stem Cells Carrying FANCD2 Mutation Differ from the Other Fanconi Anemia Complementation Groups in Terms of TGF-β1 Production.Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer.Structural basis for the functional role of the Shu complex in homologous recombination.FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM.A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency.
P2860
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P2860
The Fanconi anaemia pathway: new players and new functions.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
The Fanconi anaemia pathway: new players and new functions.
@en
type
label
The Fanconi anaemia pathway: new players and new functions.
@en
prefLabel
The Fanconi anaemia pathway: new players and new functions.
@en
P2093
P356
P1476
The Fanconi anaemia pathway: new players and new functions.
@en
P2093
Alan D D'Andrea
Prabha Sarangi
Raphael Ceccaldi
P2888
P304
P356
10.1038/NRM.2016.48
P577
2016-05-05T00:00:00Z
P6179
1017711392