A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response. - Wikidata - wikimedia - TriplyDB

A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response.

A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response.

http://www.wikidata.org/entity/Q38857831

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MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades Immune signaling by RIG-I-like receptors Ubiquitin in the activation and attenuation of innate antiviral immunity Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5 LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling A non-canonical role of the p97 complex in RIG-I antiviral signaling Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1 The C-Terminal Effector Domain of Non-Structural Protein 1 of Influenza A Virus Blocks IFN-β Production by Targeting TNF Receptor-Associated Factor 3 Functional characterization of domains of IPS-1 using an inducible oligomerization system.Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein.Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN RNA sequencing-based analysis of the spleen transcriptome following infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrations Mechanisms of MAVS regulation at the mitochondrial membrane.Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.Structural Insights into mitochondrial antiviral signaling protein (MAVS)-tumor necrosis factor receptor-associated factor 6 (TRAF6) signaling.GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome Chlamydia pneumoniae impairs the innate immune response in infected epithelial cells by targeting TRAF3 Ubiquitination in the antiviral immune response Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response.HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex.TRAF molecules in cell signaling and in human diseases UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS.The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling.Regulation of mitochondrial antiviral signaling (MAVS) expression and signaling by the mitochondria-associated endoplasmic reticulum membrane (MAM) protein Gp78.Emerging role of ubiquitination in antiviral RIG-I signaling Recognition of viruses in the cytoplasm by RLRs and other helicases--how conformational changes, mitochondrial dynamics and ubiquitination control innate immune responses.Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses.Antiviral RNA recognition and assembly by RLR family innate immune sensors.How RIG-I like receptors activate MAVS.Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.Host and Viral Modulation of RIG-I-Mediated Antiviral Immunity.IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes.Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates.Down regulation of TRIF, TLR3, and MAVS in HCV infected liver correlates with the outcome of infection.ArfGAP Domain-Containing Protein 2 (ADAP2) Integrates Upstream and Downstream Modules of RIG-I Signaling and Facilitates Type I Interferon Production.RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling.Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome.

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P2860

A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response.

http://www.wikidata.org/entity/Q38857831

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

2011年學術文章

@zh

2011年學術文章

@zh-hant

name

A functional C-terminal TRAF3- ...... of the IFN antiviral response.

@en

type

label

A functional C-terminal TRAF3- ...... of the IFN antiviral response.

@en

prefLabel

A functional C-terminal TRAF3- ...... of the IFN antiviral response.

@en

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A functional C-terminal TRAF3- ...... of the IFN antiviral response.

@en

P2093

Deshanthe Joseph-Pillai

http://www.w3.org/2001/XMLSchema#string

Eliane F Meurs

http://www.w3.org/2001/XMLSchema#string

John Hiscott

http://www.w3.org/2001/XMLSchema#string

Meztli Arguello

http://www.w3.org/2001/XMLSchema#string

Myriam Vilasco

http://www.w3.org/2001/XMLSchema#string

Qiang Sun

http://www.w3.org/2001/XMLSchema#string

Rongtuan Lin

http://www.w3.org/2001/XMLSchema#string

Steven J Werden

http://www.w3.org/2001/XMLSchema#string

Thi Lien-Anh Nguyen

http://www.w3.org/2001/XMLSchema#string

Tiejun Zhao

http://www.w3.org/2001/XMLSchema#string

P2860

SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways

Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

Peroxisomes are signaling platforms for antiviral innate immunity

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

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895-910

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scholarly article

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10.1038/CR.2011.2

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6

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21

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49723202

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21200404

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3203699

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