Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop.

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Barriers to systemic application of virus-based vectors in gene therapy: lessons from adenovirus type 5.

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Q40103248-AD596175-89AE-4CB2-8DEB-E958D6913207

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Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop.

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http://www.wikidata.org/entity/Q38866016

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

Retargeting FX-binding-ablated ...... able region 7 and the HI loop.

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type

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Retargeting FX-binding-ablated ...... able region 7 and the HI loop.

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Retargeting FX-binding-ablated ...... able region 7 and the HI loop.

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P1476

Retargeting FX-binding-ablated ...... able region 7 and the HI loop.

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P2093

Andrew H Baker

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Carolyn Clarke

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Margaret R Duffy

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Raul Alba

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P2860

HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses

Crystal structure of an anticoagulant protein in complex with the Gla domain of factor X

Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism.

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo.

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer.

Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob.

RGD inclusion in the hexon monomer provides adenovirus type 5-based vectors with a fiber knob-independent pathway for infection.

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1911-1916

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scholarly article

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10.1099/JGV.0.000505

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English

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Alan L Parker

Stuart A Nicklin

Stacy Robertson

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2016-05-16T00:00:00Z

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27189759

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5156330

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Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop.

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P2860

P2860

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop.

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type

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P1433

P1476

P2093

P2860

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P356

P407

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P698

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P1476

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P31

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P407

P433

P478

P50

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P698

P932