A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme.
about
Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparumCharacterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione.Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug targetReal-time imaging of the intracellular glutathione redox potential in the malaria parasite Plasmodium falciparumAcetaminophen reactive intermediates target hepatic thioredoxin reductaseProfiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues.Electrochemical properties of substituted 2-methyl-1,4-naphthoquinones: redox behavior predictions.Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats.Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs.1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agentsEffects of glutathione reductase inhibition on cellular thiol redox state and related systemsRecent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation.A biophysically based mathematical model for the catalytic mechanism of glutathione reductase.Thioredoxin reductase and its inhibitors.Reversible proton coupled electron transfer in a peptide-incorporated naphthoquinone amino acid.Cellular Protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of Thioredoxin Reductase through a Suicide Substrate Mechanism.Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties.Synthesis and redox-enzyme modulation by amino-1,4-dihydro-benzo[d][1,2]dithiine derivatives.Inhibition of purified bovine liver glutathione reductase with some metal ions.Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase.
P2860
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P2860
A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年學術文章
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2006年學術文章
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name
A fluoro analogue of the menad ...... of the alkylated human enzyme.
@en
type
label
A fluoro analogue of the menad ...... of the alkylated human enzyme.
@en
prefLabel
A fluoro analogue of the menad ...... of the alkylated human enzyme.
@en
P2093
P50
P356
P1476
A fluoro analogue of the menad ...... of the alkylated human enzyme.
@en
P2093
Andreas Winzer
Holger Bauer
R Heiner Schirmer
Sebastian Kühner
Susan Little
Vanessa Yardley
P304
10784-10794
P356
10.1021/JA061155V
P407
P577
2006-08-01T00:00:00Z