Tumour growth of colorectal rat liver metastases is inhibited by hepatic arterial infusion of the mTOR-inhibitor temsirolimus after portal branch ligation.

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Portal branch ligation does not counteract the inhibiting effect of temsirolimus on extrahepatic colorectal metastatic growth.

P2860

Q48252909-D0F1B6E5-E1B3-435B-BBF7-C92F7F472F0C

P2860

Tumour growth of colorectal rat liver metastases is inhibited by hepatic arterial infusion of the mTOR-inhibitor temsirolimus after portal branch ligation.

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Tumour growth of colorectal ra ...... after portal branch ligation.

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Tumour growth of colorectal ra ...... after portal branch ligation.

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Tumour growth of colorectal ra ...... after portal branch ligation.

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P1476

Tumour growth of colorectal ra ...... after portal branch ligation.

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P2093

Anika Gittler

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Anna Benz-Weißer

http://www.w3.org/2001/XMLSchema#string

Christian Ziemann

http://www.w3.org/2001/XMLSchema#string

Jens Sperling

http://www.w3.org/2001/XMLSchema#string

Michael D Menger

http://www.w3.org/2001/XMLSchema#string

Otto Kollmar

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P2860

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

Rapamycin and mTOR kinase inhibitors

Current development of mTOR inhibitors as anticancer agents

A two-stage hepatectomy procedure combined with portal vein embolization to achieve curative resection for initially unresectable multiple and bilobar colorectal liver metastases.

Portal branch ligation induces a hepatic arterial buffer response, microvascular remodeling, normoxygenation, and cell proliferation in portal blood-deprived liver tissue.

Everolimus in combination with pemetrexed in patients with advanced non-small cell lung cancer previously treated with chemotherapy: a phase I study using a novel, adaptive Bayesian dose-escalation model.

Tumour growth following portal branch ligation in an experimental model of liver metastases.

Portal vein ligation accelerates tumor growth in ligated, but not contralateral lobes

Targeting mTOR pathways in human malignancies.

Intravenous temsirolimus in cancer patients: clinical pharmacology and dosing considerations.

P2888

s10585-015-9707-4

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scholarly article

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10.1007/S10585-015-9707-4

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1004193537

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Tumour growth of colorectal rat liver metastases is inhibited by hepatic arterial infusion of the mTOR-inhibitor temsirolimus after portal branch ligation.

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P2860

P2860

Tumour growth of colorectal rat liver metastases is inhibited by hepatic arterial infusion of the mTOR-inhibitor temsirolimus after portal branch ligation.

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