Site-selective protein-modification chemistry for basic biology and drug development.
about
A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live CellsBioorthogonal Chemical Activation of Kinases in Living SystemsAntibody fragments as nanoparticle targeting ligands: a step in the right directionSelective N-terminal functionalization of native peptides and proteins.Assessing histidine tags for recruiting deoxyribozymes to catalyze peptide and protein modification reactionsA Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2).Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagentsChemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease.A structural and mechanistic study of π-clamp-mediated cysteine perfluoroarylationDNA-Catalyzed Introduction of Azide at Tyrosine for Peptide Modification.Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst.Site-Selective Modification of Proteins with Oxetanes.Visible-Light-Mediated Selective Arylation of Cysteine in Batch and Flow.Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery.Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites.Insights on the Structure, Molecular Weight, and Activity of an Antibacterial Protein-Polymer Hybrid.Tuning Enzyme/α-Zr(IV) Phosphate Nanoplate Interactions via Chemical Modification of Glucose Oxidase.Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.Engineered, highly reactive substrates of microbial transglutaminase enable protein labeling within various secondary structure elements.Recognition-then-Reaction Enables Site-Selective Bioconjugation to Proteins on Live-Cell Surfaces.Chemical biology approaches for studying posttranslational modifications.A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases.Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones.Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials.Development of Antibody-Directed Therapies: Quo Vadis?Quaternary β2,2 -Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc-Based Solid-Phase Peptide Synthesis.Proximity-Based Sortase-Mediated Ligation.Modular, bioorthogonal strategy for the controlled loading of car-go into a protein nanocage.Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins.Chemo- and Regioselective Lysine Modification on Native Proteins.Multicomponent polysaccharide-protein bioconjugation in the development of antibacterial glycoconjugate vaccine candidates.Leveraging Physiology for Precision Drug DeliveryAryl transition metal chemical warheads for protein bioconjugationIminoboronates are efficient intermediates for selective, rapid and reversible -terminal cysteine functionalisationPalladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteinsSelective N-terminal acylation of peptides and proteins with a Gly-His tag sequence
P2860
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P2860
Site-selective protein-modification chemistry for basic biology and drug development.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Site-selective protein-modification chemistry for basic biology and drug development.
@en
type
label
Site-selective protein-modification chemistry for basic biology and drug development.
@en
prefLabel
Site-selective protein-modification chemistry for basic biology and drug development.
@en
P2860
P356
P1433
P1476
Site-selective protein-modification chemistry for basic biology and drug development.
@en
P2093
Gonçalo J L Bernardes
Nikolaus Krall
P2860
P2888
P304
P356
10.1038/NCHEM.2393
P577
2015-11-30T00:00:00Z
P5875
P6179
1027221797