Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.

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Role of Bruton's tyrosine kinase in B cells and malignancies.

P2860

Q49888075-04CED056-5751-4D9C-A2ED-F959B16122A9

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Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

@zh-cn

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2017年學術文章

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Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.

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type

Item

label

Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.

@en

prefLabel

Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.

@en

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Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.

@en

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Guus F Rimmelzwaan

http://www.w3.org/2001/XMLSchema#string

Jasper Rip

http://www.w3.org/2001/XMLSchema#string

Laurens P Kil

http://www.w3.org/2001/XMLSchema#string

Marjolein J W de Bruijn

http://www.w3.org/2001/XMLSchema#string

Odilia B J Corneth

http://www.w3.org/2001/XMLSchema#string

Van T B Ta

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib

Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor

Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia

Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.

Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase.

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

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3058-3068

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scholarly article

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10.4049/JIMMUNOL.1601285

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English

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http://www.w3.org/2001/XMLSchema#string

P478

198

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Wilfried Ellmeier

Anton W Langerak

Rudi W Hendriks

Esmee K van der Ploeg

Lars W van Greuningen

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2017-03-08T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28275136

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Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.

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P2860

P2860

Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698