Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. - Wikidata - wikimedia - TriplyDB

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

http://www.wikidata.org/entity/Q38933788

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Novel drugs that target the metabolic reprogramming in renal cell cancer Fundamentals of cancer metabolism Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs A roadmap for interpreting (13)C metabolite labeling patterns from cells Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes.Metabolic rewiring in melanoma Investigating mitochondrial redox state using NADH and NADPH autofluorescence Mitochondrial pyruvate transport: a historical perspective and future research directions Metabolic pathways promoting cancer cell survival and growth Effects of Interferons and Viruses on Metabolism Impact of Ho(3+)-doping on (13)C dynamic nuclear polarization using trityl OX063 free radical Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid From Krebs to clinic: glutamine metabolism to cancer therapy.Racial disparity in metabolic regulation of cancer.Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells Modeling cancer metabolism on a genome scale.Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier.Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid β-oxidation pathway in HepG2 cells.Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet.(13) C dynamic nuclear polarization using isotopically enriched 4-oxo-TEMPO free radicals.SUMOFLUX: A Generalized Method for Targeted 13C Metabolic Flux Ratio Analysis MPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancer Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.Construction and 13 C hyperpolarization efficiency of a 180 GHz dissolution dynamic nuclear polarization system.Cancer's Fuel Choice: New Flavors for a Picky Eater Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis.Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression.The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity Reductive carboxylation supports redox homeostasis during anchorage-independent growth.Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment.Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.Metabolic requirements for cancer cell proliferation Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.Amplification of USP13 drives ovarian cancer metabolism.Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence.

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P2860

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

http://www.wikidata.org/entity/Q38933788

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2014年学术文章

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Glutamine oxidation maintains ...... ochondrial pyruvate transport.

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Glutamine oxidation maintains ...... ochondrial pyruvate transport.

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Glutamine oxidation maintains ...... ochondrial pyruvate transport.

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Glutamine oxidation maintains ...... tochondrial pyruvate transport

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Ajla T Wasti

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Bookyung Ko

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Chendong Yang

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Christopher T Hensley

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Jared Rutter

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Jessica Sudderth

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Jiyeon Kim

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Lei Jiang

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Maria Antonietta Calvaruso

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Matthew E Merritt

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P2860

Understanding the Warburg effect: the metabolic requirements of cell proliferation

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Glutamine and cancer: cell biology, physiology, and clinical opportunities

A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.

Identification and functional expression of the mitochondrial pyruvate carrier.

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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