Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining.
about
Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.Smarcal1 promotes double-strand-break repair by nonhomologous end-joining.Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery.Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line.RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression.
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Q34551194-95E6CCBE-C7F8-4F9B-8500-E89F0A2DDDD2Q35668100-40D0B8EC-2644-4299-8960-0E92A65E9B91Q37022214-B695AAE1-986E-441E-A53F-ACE817C81C34Q38768243-BFFA1426-6CF9-44B5-80A0-5EDD094900B8Q38784919-2426CE16-7A93-441E-81DF-3D2308121250Q47955849-B21F617B-594F-427D-AF70-14C0737FFC53Q48097137-DCC7250D-2A7C-424E-AE54-502A9E3D421D
P2860
Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining.
description
2014 nî lūn-bûn
@nan
2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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2014年學術文章
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2014年學術文章
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name
Rad18 and Rnf8 facilitate homo ...... of nonhomologous end joining.
@en
type
label
Rad18 and Rnf8 facilitate homo ...... of nonhomologous end joining.
@en
prefLabel
Rad18 and Rnf8 facilitate homo ...... of nonhomologous end joining.
@en
P2093
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Rad18 and Rnf8 facilitate homo ...... of nonhomologous end joining.
@en
P2093
S Kobayashi
Y Kasaishi
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P2888
P304
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10.1038/ONC.2014.371
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P577
2014-11-24T00:00:00Z
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1042844457