β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes
about
Cellular proteostasis: degradation of misfolded proteins by lysosomespH-induced molecular shedding drives the formation of amyloid fibril-derived oligomersEndocytosed 2-Microglobulin Amyloid Fibrils Induce Necrosis and Apoptosis of Rabbit Synovial Fibroblasts by Disrupting Endosomal/Lysosomal Membranes: A Novel Mechanism on the Cytotoxicity of Amyloid Fibrils.Molecular pathogenesis of human amyloidosis: Lessons from β2 -microglobulin-related amyloidosis.Analysis of Toxic Amyloid Fibril Interactions at Natively Derived Membranes by Ellipsometry.Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers.Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.Inhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide: MECHANISTIC DETAILS STUDIED BY SPECTROSCOPY IN COMBINATION WITH MICROSCOPYThe small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death.The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism
P2860
Q28079032-7400FD6C-6A7B-4B9B-AB0D-D1A9D305EE80Q35590322-57F4B638-EBB0-4BD2-A337-25412A2F59E0Q35793465-3D18E551-AD28-41EF-A758-C97B3B55F958Q38771098-5E50B52B-5D48-4807-AA4F-D84CCE7F3A60Q38853212-044AC4D4-87DF-4A35-9121-4BAD8F90F213Q41774231-342F1282-598D-4082-82FD-4815A7C34820Q42038712-E803C00D-3929-4847-AFCA-35AF1E025876Q42733322-E29ED86D-45B9-4A64-BC15-EC1B18D54C92Q48139412-29D69D34-A016-4127-ACBF-552E1A1DE1ADQ48507581-BEEA7AD5-D879-4464-94F6-F7FD4A331077Q57787220-E3037E30-9E2D-4D39-A34B-4381BB6EDF70
P2860
β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
β2-microglobulin amyloid fibri ...... otein degradation by lysosomes
@en
β2-microglobulin amyloid fibri ...... otein degradation by lysosomes
@en-gb
type
label
β2-microglobulin amyloid fibri ...... otein degradation by lysosomes
@en
β2-microglobulin amyloid fibri ...... otein degradation by lysosomes
@en-gb
prefLabel
β2-microglobulin amyloid fibri ...... otein degradation by lysosomes
@en
β2-microglobulin amyloid fibri ...... otein degradation by lysosomes
@en-gb
P2093
P2860
P50
P356
P1154
2-s2.0-84919799070
P1476
β2-microglobulin amyloid fibri ...... otein degradation by lysosomes
@en
P2093
Andrew L Hellewell
Kevin W Tipping
Matthew P Jackson
Morwenna Y Porter
Toral Jakhria
P2860
P304
35781-35794
P356
10.1074/JBC.M114.586222
P407
P5530
P577
2014-11-05T00:00:00Z
P6179
1011968577