Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression.
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Nonviral oncogenic antigens and the inflammatory signals driving early cancer development as targets for cancer immunopreventionMetformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells.Metformin inhibits the prometastatic effect of sorafenib in hepatocellular carcinoma by upregulating the expression of TIP30.Expression of Phosphorylated AMP-Activated Protein Kinase Predicts Response to Transarterial Chemoembolization in Postoperative Cases of Hepatocellular Carcinoma.Metformin and gefitinib cooperate to inhibit bladder cancer growth via both AMPK and EGFR pathways joining at Akt and ErkLipid raft localization of epidermal growth factor receptor alters matrix metalloproteinase-1 expression in SiHa cells via the MAPK/ERK signaling pathway.Metformin enhances the radiosensitivity of human liver cancer cells to γ-rays and carbon ion beams.Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway.Proteomic modulation in breast tumors after metformin exposure: results from a "window of opportunity" trial.Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches.Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells.Metformin and AICAR regulate NANOG expression via the JNK pathway in HepG2 cells independently of AMPK.Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway.Combinational strategies of metformin and chemotherapy in cancers.Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro.Chinese herbal formula QHF inhibits liver cancer cell invasion and migrationMetformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation.Hint1 suppresses migration and invasion of hepatocellular carcinoma cells in vitro by modulating girdin activity.Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo.Metformin inhibits the migration and invasion of esophageal squamous cell carcinoma cells by downregulating the protein kinase B signaling pathway.β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways.Targeting P-glycoprotein expression and cancer cell energy metabolism: combination of metformin and 2-deoxyglucose reverses the multidrug resistance of K562/Dox cells to doxorubicin.Anti-tumoral effects of exercise on hepatocellular carcinoma growth.Effect of hypoglycemic agents on survival outcomes of lung cancer patients with diabetes mellitus: A meta-analysis.Metformin and blood cancers
P2860
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P2860
Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Metformin inhibits the invasio ...... uces uPA and MMP-9 expression.
@en
type
label
Metformin inhibits the invasio ...... uces uPA and MMP-9 expression.
@en
prefLabel
Metformin inhibits the invasio ...... uces uPA and MMP-9 expression.
@en
P2093
P2860
P1433
P1476
Metformin inhibits the invasio ...... uces uPA and MMP-9 expression.
@en
P2093
Jen-Pi Tsai
Meng-Ju Tang
Shu-Ching Hsieh
Shun-Fa Yang
Yi-Hsien Hsieh
P2860
P2888
P304
P356
10.1007/S00726-014-1838-4
P577
2014-09-23T00:00:00Z