about
Extending enzyme molecular recognition with an expanded amino acid alphabet.All atom NMDA receptor transmembrane domain model development and simulations in lipid bilayers and water.ISAMBARD: an open-source computational environment for biomolecular analysis, modelling and design.Vaccine nanoparticles for protection against HIV infection.Computational tools help improve protein stability but with a solubility tradeoff.Global analysis of protein folding using massively parallel design, synthesis, and testing.Targeting and delivery of therapeutic enzymes.Cooperative colloidal self-assembly of metal-protein superlattice wiresDesign of energy-transducing artificial cellsAn intrinsically disordered linker controlling the formation and the stability of the bacterial flagellar hook.Principles for computational design of binding antibodies.De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy.Improving membrane protein expression by optimizing integration efficiency.Frustration, function and folding.A tyrosinase, mTyr-CNK, that is functionally available as a monophenol monooxygenase.Producing membrane proteins one simulation at a time.Conversion of microbial rhodopsins: insights into functionally essential elements and rational protein engineering.Artificial antibody created by conformational reconstruction of the complementary-determining region on gold nanoparticles.Hierarchical design of artificial proteins and complexes toward synthetic structural biology.Directed evolution to improve protein folding in vivo.Design of artificial metalloproteins/metalloenzymes by tuning noncovalent interactions.Controlling the lectin recognition of glycopolymers via distance arrangement of sugar blocks.De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles.Comprehensive computational design of ordered peptide macrocycles.SCooP: an accurate and fast predictor of protein stability curves as a function of temperature.Unraveling co-translational protein folding: Concepts and methods.Computational Redesign of Acyl-ACP Thioesterase with Improved Selectivity toward Medium-Chain-Length Fatty Acids.Exploring sequence-function space of a poplar glutathione transferase using designed information-rich gene variants.Strand Displacement in Coiled-Coil Structures: Controlled Induction and Reversal of Proximity.Symmetry-Directed Self-Assembly of a Tetrahedral Protein Cage Mediated by de Novo-Designed Coiled Coils.Designed Heme-Cage β-Sheet Miniproteins.The "OK, Molly" Chemistry.The finite number of global motion patterns available to symmetric protein complexes.Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex.Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation.Engineered control of enzyme structural dynamics and function.A four-helix bundle DNA nanostructure with binding pockets for pyrimidine nucleotides.Recent advances in automated protein design and its future challenges.Foldamer Tertiary Structure through Sequence-Guided Protein Backbone Alteration.Real-time magnetic actuation of DNA nanodevices via modular integration with stiff micro-levers.
P2860
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P2860
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
The coming of age of de novo protein design.
@en
type
label
The coming of age of de novo protein design.
@en
prefLabel
The coming of age of de novo protein design.
@en
P50
P356
P1433
P1476
The coming of age of de novo protein design.
@en
P2888
P304
P356
10.1038/NATURE19946
P407
P577
2016-09-14T00:00:00Z
P6179
1023334970