Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. - Wikidata - wikimedia - TriplyDB

Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.

Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.

http://www.wikidata.org/entity/Q38955683

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Pancreatic cancer stem cell markers and exosomes - the incentive push Cancer stem cells (CSCs), cervical CSCs and targeted therapies Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets Therapeutic strategies targeting cancer stem cells Remodelling the extracellular matrix in development and disease Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells Overcoming therapeutic resistance in glioblastoma: the way forward CD44-mediated adhesion to hyaluronic acid contributes to mechanosensing and invasive motility Intercellular communication in malignant pleural mesothelioma: properties of tunneling nanotubes.Chitosan promotes cancer progression and stem cell properties in association with Wnt signaling in colon and hepatocellular carcinoma cells.Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival.Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity.Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma.A Cell-Surface Membrane Protein Signature for Glioblastoma.Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram.Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin-NF-κB-HIF-1α pathway Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization.Histological Characterization of the Tumorigenic "Peri-Necrotic Niche" Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis.Nanoparticles for Targeting Intratumoral Hypoxia: Exploiting a Potential Weakness of Glioblastoma.Distinct Intracellular Domain Substrate Modifications Selectively Regulate Ectodomain Cleavage of NRG1 or CD44.Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas Identification of therapeutic targets for glioblastoma by network analysis.Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.The Combined Influence of Hydrogel Stiffness and Matrix-Bound Hyaluronic Acid Content on Glioblastoma Invasion.The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors.Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal.The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis.Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells.Metastasis prevention by targeting the dormant niche.The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-)Interleukin-6 enhances cancer stemness and promotes metastasis of hepatocellular carcinoma via up-regulating osteopontin expression.HMGA2 sustains self-renewal and invasiveness of glioma-initiating cells.CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect.

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Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.

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Amanda M Katz

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Boyoung Wee

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Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration

Identification of a cancer stem cell in human brain tumors

Mechanism and biological significance of CD44 cleavage

TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

Critical appraisal of the side population assay in stem cell and cancer stem cell research

Hypoxia--a key regulatory factor in tumour growth

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