Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.
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Direct acting antivirals for the treatment of chronic viral hepatitisStructure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNAViral replication. Structural basis for RNA replication by the hepatitis C virus polymeraseSimilar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencingBiochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA PolymeraseNaturally occurring drug resistance associated variants to hepatitis C virus direct-acting antiviral agents in treatment-naive HCV genotype 1b-infected patients in China.Direct-acting Antiviral Agents for the Treatment of Chronic Hepatitis C Virus Infection.NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naïve patients.Hepatitis C virus resistance to new specifically-targeted antiviral therapy: A public health perspective.Natural prevalence of hepatitis C virus (HCV) variants resistant to protease and polymerase inhibitors in patients infected with HCV genotype 1 in Tunisia.Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.Discontinued drugs in 2012 - 2013: hepatitis C virus infection.Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.Prevalence and characteristics of naturally occurring sofosbuvir resistance-associated variants in patients with hepatitis C virus genotype 1b infection.Regulatory evaluation of antiviral drug resistance in the era of next-generation sequencing.Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance.Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir.All-oral therapy with nucleotide inhibitors sofosbuvir and GS-0938 for 14 days in treatment-naive genotype 1 hepatitis C (nuclear).Hepatitis C virus variants with decreased sensitivity to direct-acting antivirals (DAAs) were rarely observed in DAA-naive patients prior to treatment.Naturally Occurring Resistance-Associated Variants to Hepatitis C Virus Direct-Acting Antiviral Agents in Treatment-Naive HCV Genotype 6a-Infected Patients.Fluorinated nucleosides as an important class of anticancer and antiviral agents.
P2860
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P2860
Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Hepatitis C virus nucleotide i ...... mutations within replicon RNA.
@en
type
label
Hepatitis C virus nucleotide i ...... mutations within replicon RNA.
@en
prefLabel
Hepatitis C virus nucleotide i ...... mutations within replicon RNA.
@en
P2093
P2860
P356
P1433
P1476
Hepatitis C virus nucleotide i ...... mutations within replicon RNA.
@en
P2093
Angela M Lam
Christine Espiritu
Holly M Micolochick Steuer
Michael J Otto
Phillip A Furman
Shalini Bansal
Veronique Zennou
P2860
P304
12334-12342
P356
10.1128/JVI.05639-11
P407
P577
2011-09-28T00:00:00Z