Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation. - Wikidata - wikimedia - TriplyDB

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.

http://www.wikidata.org/entity/Q38962089

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Tribbles in normal and malignant haematopoiesis The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.Differential expression of alternatively spliced transcripts related to energy metabolism in colorectal cancer.Nonstructural 3 Protein of Hepatitis C Virus Modulates the Tribbles Homolog 3/Akt Signaling Pathway for Persistent Viral Infection.A novel crosstalk between CCAR2 and AKT pathway in the regulation of cancer cell proliferation TRB3 is elevated in psoriasis vulgaris lesions and mediates HaCaT cells proliferation in vitro.Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis.Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors The integrated stress response.Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways.TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.TUSC2 downregulates PD-L1 expression in non-small cell lung cancer (NSCLC).A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair.Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.The Drosophila melanogaster tribbles pseudokinase is necessary for proper memory formation.Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts.The long non-coding RNA FOXD2-AS1 promotes bladder cancer progression and recurrence through a positive feedback loop with Akt and E2F1.Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

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Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.

http://www.wikidata.org/entity/Q38962089

description

2014 nî lūn-bûn

@nan

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

2014年论文

@zh

2014年论文

@zh-cn

name

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.

@en

type

label

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.

@en

prefLabel

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.

@en

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Cell Death & Differentiation

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Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

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A M Aransay

http://www.w3.org/2001/XMLSchema#string

A Rodríguez

http://www.w3.org/2001/XMLSchema#string

D Dávila

http://www.w3.org/2001/XMLSchema#string

D Mosén-Ansorena

http://www.w3.org/2001/XMLSchema#string

E García-Taboada

http://www.w3.org/2001/XMLSchema#string

I López-Valero

http://www.w3.org/2001/XMLSchema#string

J L Iovanna

http://www.w3.org/2001/XMLSchema#string

J María Flores

http://www.w3.org/2001/XMLSchema#string

M Guzmán

http://www.w3.org/2001/XMLSchema#string

M Quintanilla

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

mTOR: from growth signal integration to cancer, diabetes and ageing

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

Pten is essential for embryonic development and tumour suppression

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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131-144

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scholarly article

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10.1038/CDD.2014.133

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1

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22

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Sheila E. Francis

Cristina Sánchez

Endre Kiss-Toth

Guillermo Velasco

Arkaitz Carracedo

Eduardo Pérez-Gómez

P Zúñiga-García

P577

2014-08-29T00:00:00Z

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265177926

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25168244

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4262779

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